粒细胞趋化蛋白/白细胞介素-8可诱导兔皮肤出现血浆渗漏和中性粒细胞聚集。
Granulocyte chemotactic protein/interleukin-8 induces plasma leakage and neutrophil accumulation in rabbit skin.
作者信息
Rampart M, Van Damme J, Zonnekeyn L, Herman A G
机构信息
Laboratory of Experimental Pharmacology, University of Antwerp, Belgium.
出版信息
Am J Pathol. 1989 Jul;135(1):21-5.
Abstract
Granulocyte chemotactic protein/Interleukin-8 (GCP/IL-8), purified to homogeneity from endotoxin- or mitogen-stimulated human mononuclear cells, was injected intradermally into rabbits to evaluate the proinflammatory properties of this novel cytokine. In the presence of a vasodilator substance, pmol amounts of GCP/IL-8 induced neutrophil accumulation that was fast in onset, relatively short of duration (half life 60 to 70 minutes), and was associated with a parallel time course of plasma protein extravasation. GCP/IL-8-induced edema formation was found to be neutrophil dependent. These data provide evidence that GCP/IL-8 fulfills two important criteria for consideration as an inflammatory mediator. It is possible that endogenous GCP/IL-8, if produced locally by tissue macrophages, may contribute to the initiation of the inflammatory response to infection.
摘要
从内毒素或丝裂原刺激的人单核细胞中纯化至同质的粒细胞趋化蛋白/白细胞介素-8（GCP/IL-8），经皮内注射到兔体内，以评估这种新型细胞因子的促炎特性。在存在血管扩张物质的情况下，皮摩尔量的GCP/IL-8可诱导中性粒细胞聚集，其起效迅速，持续时间相对较短（半衰期60至70分钟），并与血浆蛋白外渗的平行时间进程相关。发现GCP/IL-8诱导的水肿形成依赖于中性粒细胞。这些数据提供了证据，表明GCP/IL-8符合作为炎症介质考虑的两个重要标准。如果内源性GCP/IL-8由组织巨噬细胞在局部产生，则可能有助于启动对感染的炎症反应。
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