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本文引用的文献

1
Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.人重组肿瘤坏死因子对中性粒细胞与脐静脉内皮细胞黏附的刺激作用。
Proc Natl Acad Sci U S A. 1985 Dec;82(24):8667-71. doi: 10.1073/pnas.82.24.8667.
2
Membrane-cytoskeleton interactions and the regulation of chemotactic peptide-induced activation of human granulocytes: the effects of dihydrocytochalasin B.膜-细胞骨架相互作用与趋化肽诱导的人粒细胞激活的调节：二氢细胞松弛素B的作用
J Cell Biochem. 1985;27(3):241-53. doi: 10.1002/jcb.240270306.
3
Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes.肿瘤坏死因子对单核细胞和多形核白细胞具有趋化作用。
J Immunol. 1987 Mar 1;138(5):1469-74.
4
In vivo inflammatory activity of epidermal cell-derived thymocyte activating factor and recombinant interleukin 1 in the mouse.表皮细胞衍生的胸腺细胞激活因子及重组白细胞介素1在小鼠体内的炎性活性
J Clin Invest. 1986 Mar;77(3):1020-7. doi: 10.1172/JCI112354.
5
Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: partial characterization and separation from interleukin 1 (IL 1).脂多糖（LPS）刺激的人血单核白细胞产生的中性粒细胞趋化因子：部分特性及与白细胞介素1（IL-1）的分离
J Immunol. 1987 Aug 1;139(3):788-93.
6
Separation and comparison of two monokines with lymphocyte-activating factor activity: IL-1 beta and hybridoma growth factor (HGF). Identification of leukocyte-derived HGF as IL-6.具有淋巴细胞激活因子活性的两种单核因子的分离与比较：白细胞介素-1β和杂交瘤生长因子（HGF）。鉴定源自白细胞的HGF为白细胞介素-6。
J Immunol. 1988 Mar 1;140(5):1534-41.
7
Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor.人单核细胞衍生的中性粒细胞趋化因子（MDNCF）的分子克隆以及白细胞介素1和肿瘤坏死因子对MDNCF mRNA的诱导作用
J Exp Med. 1988 Jun 1;167(6):1883-93. doi: 10.1084/jem.167.6.1883.
8
A novel, NH2-terminal sequence-characterized human monokine possessing neutrophil chemotactic, skin-reactive, and granulocytosis-promoting activity.一种新型的、具有嗜中性粒细胞趋化活性、皮肤反应活性和促进粒细胞增多活性的、以氨基末端序列为特征的人单核因子。
J Exp Med. 1988 Apr 1;167(4):1364-76. doi: 10.1084/jem.167.4.1364.
9
Synergy between tumour necrosis factor alpha and interleukin-1 in the induction of polymorphonuclear leukocyte migration during inflammation.肿瘤坏死因子α与白细胞介素-1在炎症过程中诱导多形核白细胞迁移方面的协同作用。
J Leukoc Biol. 1988 Apr;43(4):349-56. doi: 10.1002/jlb.43.4.349.
10
Stimulation of neutrophils by tumor necrosis factor.肿瘤坏死因子对中性粒细胞的刺激。
J Immunol. 1986 Jun 1;136(11):4220-5.

人粒细胞趋化肽（白细胞介素-8）作为一种特异性中性粒细胞脱颗粒剂：与其他单核因子的比较。

Human granulocyte chemotactic peptide (IL-8) as a specific neutrophil degranulator: comparison with other monokines.

作者信息

Willems J, Joniau M, Cinque S, van Damme J

机构信息

Interdisciplinary Research Center, K.U. Leuven Campus Kortrijk, Belgium.

出版信息

Immunology. 1989 Aug;67(4):540-2.

PMID:2670752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1385329/
Abstract

The influence of human monocyte-derived chemotactic peptide (GCP/IL-8) on degranulation of neutrophils was investigated in relation to that of other monokines. GCP/IL-8 promoted a dose-dependent release of lactoferrin from specific granules but had no effect on enzyme release from primary granules. From the other monokines that were tested, tumour necrosis factor alpha (TNF alpha) also induced degranulation, while IL-1 beta and IL-6 scored negatively. TNF alpha-induced lactoferrin release was enhanced by cytochalasin B pretreatment of the granulocytes, while GCP/IL-8-promoted degranulation was not. In contrast to GCP, TNF alpha also caused the release of LDH, suggesting a non-specific cell destruction. These observations further support the view that, unlike the other monokines, GCP/IL-8 is a true and specific granulocyte activator.

摘要

研究了人单核细胞衍生趋化肽（GCP/IL-8）与其他单核因子相比对中性粒细胞脱颗粒的影响。GCP/IL-8促进乳铁蛋白从特异性颗粒中呈剂量依赖性释放，但对初级颗粒中的酶释放没有影响。在测试的其他单核因子中，肿瘤坏死因子α（TNFα）也诱导脱颗粒，而IL-1β和IL-6则无此作用。细胞松弛素B预处理粒细胞可增强TNFα诱导的乳铁蛋白释放，而GCP/IL-8促进的脱颗粒则不受影响。与GCP不同，TNFα还导致乳酸脱氢酶释放，提示非特异性细胞破坏。这些观察结果进一步支持了以下观点，即与其他单核因子不同，GCP/IL-8是一种真正的特异性粒细胞激活剂。