人粒细胞趋化肽（白细胞介素-8）作为一种特异性中性粒细胞脱颗粒剂：与其他单核因子的比较。
Human granulocyte chemotactic peptide (IL-8) as a specific neutrophil degranulator: comparison with other monokines.
作者信息
Willems J, Joniau M, Cinque S, van Damme J
机构信息
Interdisciplinary Research Center, K.U. Leuven Campus Kortrijk, Belgium.
出版信息
Immunology. 1989 Aug;67(4):540-2.
Abstract
The influence of human monocyte-derived chemotactic peptide (GCP/IL-8) on degranulation of neutrophils was investigated in relation to that of other monokines. GCP/IL-8 promoted a dose-dependent release of lactoferrin from specific granules but had no effect on enzyme release from primary granules. From the other monokines that were tested, tumour necrosis factor alpha (TNF alpha) also induced degranulation, while IL-1 beta and IL-6 scored negatively. TNF alpha-induced lactoferrin release was enhanced by cytochalasin B pretreatment of the granulocytes, while GCP/IL-8-promoted degranulation was not. In contrast to GCP, TNF alpha also caused the release of LDH, suggesting a non-specific cell destruction. These observations further support the view that, unlike the other monokines, GCP/IL-8 is a true and specific granulocyte activator.
摘要
研究了人单核细胞衍生趋化肽（GCP/IL-8）与其他单核因子相比对中性粒细胞脱颗粒的影响。GCP/IL-8促进乳铁蛋白从特异性颗粒中呈剂量依赖性释放，但对初级颗粒中的酶释放没有影响。在测试的其他单核因子中，肿瘤坏死因子α（TNFα）也诱导脱颗粒，而IL-1β和IL-6则无此作用。细胞松弛素B预处理粒细胞可增强TNFα诱导的乳铁蛋白释放，而GCP/IL-8促进的脱颗粒则不受影响。与GCP不同，TNFα还导致乳酸脱氢酶释放，提示非特异性细胞破坏。这些观察结果进一步支持了以下观点，即与其他单核因子不同，GCP/IL-8是一种真正的特异性粒细胞激活剂。
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