Pan L, Diss T C, Cunningham D, Isaacson P G
Department of Histopathology, University College and Middlesex School of Medicine, London, England.
Am J Pathol. 1989 Jul;135(1):7-11.
The bcl-2 gene rearrangement representing t(14:18) chromosomal translocation is the most frequent karyotypic abnormality in non-Hodgkin's lymphomas of follicle center-cell lineage. By using three bcl-2 DNA probes, 21 cases of non-Hodgkin's B cell lymphoma arising from gastrointestinal mucosa and eight cases of follicular lymphomas were examined. No rearrangement of the gene could be detected in the group of gastrointestinal lymphomas, although it was identified in 75% of the follicular lymphomas. The findings suggest that these two groups of lymphomas are not a family at genetic level and support the earlier suggestion that B cell lymphomas arising from gastrointestinal mucosa-associated lymphoid tissue are not of follicle center-cell lineage.
代表t(14:18)染色体易位的bcl-2基因重排是非霍奇金滤泡中心细胞系淋巴瘤中最常见的核型异常。通过使用三种bcl-2 DNA探针，对21例源自胃肠道黏膜的非霍奇金B细胞淋巴瘤和8例滤泡性淋巴瘤进行了检测。在胃肠道淋巴瘤组中未检测到该基因的重排，尽管在75%的滤泡性淋巴瘤中发现了这种重排。这些发现表明，这两组淋巴瘤在基因水平上并非同源，支持了早期的观点，即源自胃肠道黏膜相关淋巴组织的B细胞淋巴瘤并非滤泡中心细胞系。
