Acer Semra, Oğuzhanoğlu Attila, Çetin Ebru Nevin, Ongun Nedim, Pekel Gökhan, Kaşıkçı Alper, Yağcı Ramazan
Department of Ophthalmology, Kinikli Kampusu, Pamukkale University, Denizli, TR, 20100, Turkey.
Department of Neurology, Kinikli Kampusu, Pamukkale University, Denizli, Turkey.
BMC Ophthalmol. 2016 Jan 4;16:1. doi: 10.1186/s12886-015-0180-2.
To evaluate the ocular pulse amplitude (OPA), the posterior pole asymmetry analysis (PPAA), the peripapillary retinal nerve fiber layer (RNFL) thickness, the ganglion cell layer (GCL) thickness, macular thickness and visual field testing in migraine patients without aura.
In this prospective, cross-sectional and comparative study 38 migraine patients and 44 age and sex matched controls were included. OPA was measured by dynamic contour tonometry (DCT), PPAA, RNFL, GCL and macular thickness were measured by Heidelberg Spectral Domain Optical Coherence Tomography (SD-OCT) and standard perimetry was performed using the Humphrey automated field analyzer.
The difference in OPA was not statistically significant between the two groups (p ≥ 0.05). In the PPAA there was no significant difference between two hemispheres in each eye (p ≥ 0.05). The RNFL thickness was significantly reduced in the temporal and nasal superior sectors in the migraine group (p ≤ 0.05). The GCL and macular thickness measurements were thinner in migraine patients but the difference between groups was not statistically significant (p ≥ 0.05). There was no correlation between RNFL, GCL, macular thickness measurements and OPA values. There was no significant difference in the mean deviation (MD) and pattern standard deviation (PSD) between the two groups (p ≥ 0.05).
Migraine patients without aura have normal OPA values, no significant asymmetry of the posterior pole and decreased peripapillary RNFL thickness in the temporal and nasal superior sectors compared with controls. These findings suggest that there is sectorial RNFL thinning in migraine patients without aura and pulsative choroidal blood flow may not be affected during the chronic course of disease.
评估无先兆偏头痛患者的眼脉搏振幅（OPA）、后极不对称分析（PPAA）、视乳头周围视网膜神经纤维层（RNFL）厚度、神经节细胞层（GCL）厚度、黄斑厚度及视野检查情况。
在这项前瞻性、横断面比较研究中，纳入了38例偏头痛患者和44例年龄及性别匹配的对照者。采用动态轮廓眼压计（DCT）测量OPA，使用海德堡光谱域光学相干断层扫描（SD - OCT）测量PPAA、RNFL、GCL及黄斑厚度，并使用Humphrey自动视野分析仪进行标准视野检查。
两组间OPA差异无统计学意义（p≥0.05）。在PPAA中，每只眼的两个半球之间无显著差异（p≥0.05）。偏头痛组颞侧和鼻侧上象限的RNFL厚度显著降低（p≤0.05）。偏头痛患者的GCL和黄斑厚度测量值较薄，但组间差异无统计学意义（p≥0.05）。RNFL、GCL、黄斑厚度测量值与OPA值之间无相关性。两组间平均偏差（MD）和模式标准偏差（PSD）无显著差异（p≥0.05）。
无先兆偏头痛患者的OPA值正常，后极无明显不对称，与对照组相比，颞侧和鼻侧上象限的视乳头周围RNFL厚度降低。这些发现表明，无先兆偏头痛患者存在RNFL扇形变薄，且在疾病慢性病程中搏动性脉络膜血流可能未受影响。
