Wang Yu, Li Da-Hong, Li Zhan-Lin, Sun Yan-Jun, Hua Hui-Ming, Liu Tao, Bai Jiao
Department of Natural Products Chemistry, School of Pharmacy, China Medical University, Shenyang 110122, China.
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Molecules. 2015 Dec 28;21(1):E31. doi: 10.3390/molecules21010031.
Two new β-bergamotane sesquiterpenoids, E-β-trans-5,8,11-trihydroxybergamot-9-ene (1) and β-trans-2β,5,15-trihydroxybergamot-10-ene (2), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with three known terpenoids 3-5. Their structures were determined by spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were measured in vitro. Compound 4 exhibited potent activity against the U937 cell line with an IC50 value of 4.2 μM.
从海洋来源的烟曲霉YK-7中分离出两种新的β-佛手柑烷倍半萜类化合物，E-β-反式-5,8,11-三羟基佛手柑-9-烯（1）和β-反式-2β,5,15-三羟基佛手柑-10-烯（2），以及三种已知的萜类化合物3-5。通过光谱方法（一维和二维核磁共振、高分辨电喷雾电离质谱）确定了它们的结构。体外测定了它们对人白血病单核细胞淋巴瘤U937和人前列腺癌PC-3细胞系的抗增殖作用。化合物4对U937细胞系表现出较强的活性，IC50值为4.2 μM。
