Malda Jos, Boere Janneke, van de Lest Chris H A, van Weeren P René, Wauben Marca H M
Nat Rev Rheumatol. 2016 Apr;12(4):243-9. doi: 10.1038/nrrheum.2015.170.
Cell-derived extracellular vesicles (EVs), present in synovial fluid and cartilage extracellular matrix (ECM), are involved in joint development and in the regulation of joint homeostasis. Although the exact function of EVs in these processes remains incompletely defined, the knowledge already acquired in this field suggests a role for these EVs as biomarkers of joint disease, and as a new tool to restore joint homeostasis and enhance articular tissue regeneration. In addition to direct injection of therapeutic EVs into the target site, surface coating of scaffolds and embedding of EVs in hydrogels might also lead to novel therapeutic possibilities. Based on the existing literature of EVs in synovial fluid and articular tissues, and investigation of the molecular factors (including microRNAs) active in joint homeostasis (or during its disturbance), we postulate novel perspectives for the implementation of EVs as a regenerative medicine approach in joint repair.
细胞衍生的细胞外囊泡（EVs）存在于滑液和软骨细胞外基质（ECM）中，参与关节发育和关节稳态的调节。尽管EVs在这些过程中的确切功能仍未完全明确，但该领域已获得的知识表明，这些EVs可作为关节疾病的生物标志物，并作为恢复关节稳态和促进关节组织再生的新工具。除了将治疗性EVs直接注射到靶部位外，对支架进行表面涂层以及将EVs嵌入水凝胶中也可能带来新的治疗可能性。基于关于滑液和关节组织中EVs的现有文献，以及对关节稳态（或其紊乱期间）中活跃的分子因子（包括微小RNA）的研究，我们提出了将EVs作为关节修复中的再生医学方法应用的新观点。
