Lei Yang, Zhang Qingfei, Kuang Gaizheng, Wang Xiaochen, Fan Qihui, Ye Fangfu
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health) Wenzhou Institute University of Chinese Academy of Sciences Wenzhou Zhejiang China.
Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing China.
Smart Med. 2022 Dec 27;1(1):e20220014. doi: 10.1002/SMMD.20220014. eCollection 2022 Dec.
Osteoarthritis (OA) is a common disease that endangers millions of middle-aged and elderly people worldwide. Researchers from different fields have made great efforts and achieved remarkable progress in the pathogenesis and treatment of OA. However, there is still no cure for OA. In this review, we discuss the pathogenesis of OA and summarize the current clinical therapies. Moreover, we introduce various natural and synthetic biomaterials for drug release, cartilage transplantation, and joint lubricant during the OA treatment. We also present our perspectives and insights on OA treatment in the future. We hope that this review will foster communication and collaboration among biological, clinical, and biomaterial researchers, paving the way for OA therapeutic breakthroughs.
骨关节炎（OA）是一种常见疾病，危害着全球数百万的中老年人。来自不同领域的研究人员在OA的发病机制和治疗方面付出了巨大努力并取得了显著进展。然而，OA仍然无法治愈。在这篇综述中，我们讨论了OA的发病机制并总结了当前的临床治疗方法。此外，我们介绍了在OA治疗过程中用于药物释放、软骨移植和关节润滑的各种天然和合成生物材料。我们还阐述了对未来OA治疗的观点和见解。我们希望这篇综述能够促进生物学、临床和生物材料研究人员之间的交流与合作，为OA治疗的突破铺平道路。
