• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Systemic lupus erythematosus in 2015: Cellular and metabolic requirements of effector T cells.

作者信息

Tsokos George C

机构信息

Division of Rheumatology, Beth Israel Deaconess Medical Centre, Harvard Medical School, Harvard University, 330 Brookline Avenue, CLS937 Boston, Massachusetts 02215, USA.

出版信息

Nat Rev Rheumatol. 2016 Feb;12(2):74-6. doi: 10.1038/nrrheum.2015.178. Epub 2016 Jan 5.

DOI:10.1038/nrrheum.2015.178
PMID:26729463
Abstract
摘要

相似文献

1
Systemic lupus erythematosus in 2015: Cellular and metabolic requirements of effector T cells.2015年的系统性红斑狼疮：效应T细胞的细胞及代谢需求
Nat Rev Rheumatol. 2016 Feb;12(2):74-6. doi: 10.1038/nrrheum.2015.178. Epub 2016 Jan 5.
2
Immune Cell Metabolism in Systemic Lupus Erythematosus.系统性红斑狼疮中的免疫细胞代谢
Curr Rheumatol Rep. 2016 Nov;18(11):66. doi: 10.1007/s11926-016-0615-7.
3
Immune cell signaling and gene transcription in human lupus: the time has come.人类狼疮中的免疫细胞信号传导与基因转录：时机已至。
Int Rev Immunol. 2004 May-Aug;23(3-4):221-4. doi: 10.1080/08830180490452530.
4
Pathogenetic aspects of systemic lupus erythematosus with an emphasis on regulatory T cells.系统性红斑狼疮的发病机制研究进展——以调节性 T 细胞为例
J Autoimmun. 2010 Nov;35(3):269-75. doi: 10.1016/j.jaut.2010.06.018. Epub 2010 Jul 16.
5
Regulatory CD4+ T cells promote B cell anergy in murine lupus.调节性 CD4+ T 细胞可促进鼠狼疮中的 B 细胞失能。
J Immunol. 2014 May 1;192(9):4069-73. doi: 10.4049/jimmunol.1302897. Epub 2014 Mar 26.
6
Does the BAFF dysregulation play a major role in the pathogenesis of systemic lupus erythematosus?B淋巴细胞刺激因子（BAFF）失调在系统性红斑狼疮发病机制中起主要作用吗？
J Autoimmun. 2008 Feb-Mar;30(1-2):63-7. doi: 10.1016/j.jaut.2007.11.001. Epub 2007 Dec 21.
7
Increased interleukin 21 and follicular helper T-like cells and reduced interleukin 10+ B cells in patients with new-onset systemic lupus erythematosus.新诊断系统性红斑狼疮患者中白细胞介素 21 和滤泡辅助 T 样细胞增加，白细胞介素 10+B 细胞减少。
J Rheumatol. 2014 Sep;41(9):1781-92. doi: 10.3899/jrheum.131025. Epub 2014 Jul 15.
8
[B lymphocyte-dependent or independent suppressor T cell abnormalities in systemic lupus erythematosus].[系统性红斑狼疮中B淋巴细胞依赖或非依赖的抑制性T细胞异常]
Nihon Naika Gakkai Zasshi. 1982 Sep 10;71(9):1237-44.
9
T-regulatory cells in systemic lupus erythematosus.系统性红斑狼疮中的调节性T细胞。
Lupus. 2008 May;17(5):421-5. doi: 10.1177/0961203308090028.
10
OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response.OX40配体通过促进滤泡辅助性T细胞反应参与人类狼疮发病机制。
Immunity. 2015 Jun 16;42(6):1159-70. doi: 10.1016/j.immuni.2015.05.012. Epub 2015 Jun 9.

引用本文的文献

1
Glutaminolysis is a Potential Therapeutic Target for Kidney Diseases.谷氨酰胺分解是肾脏疾病的一个潜在治疗靶点。
Diabetes Metab Syndr Obes. 2024 Jul 23;17:2789-2807. doi: 10.2147/DMSO.S471711. eCollection 2024.
2
Diet and Hygiene in Modulating Autoimmunity During the Pandemic Era.疫情时代饮食与卫生对自身免疫的调节
Front Immunol. 2022 Jan 5;12:749774. doi: 10.3389/fimmu.2021.749774. eCollection 2021.
3
Clinical efficacy and safety of sirolimus in systemic lupus erythematosus: a real-world study and meta-analysis.西罗莫司治疗系统性红斑狼疮的临床疗效与安全性：一项真实世界研究及荟萃分析

本文引用的文献

1
Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases.mTOR（雷帕霉素作用靶点）在风湿性疾病中的激活
Nat Rev Rheumatol. 2016 Mar;12(3):169-82. doi: 10.1038/nrrheum.2015.172. Epub 2015 Dec 24.
2
T cell metabolism drives immunity.T细胞代谢驱动免疫。
J Exp Med. 2015 Aug 24;212(9):1345-60. doi: 10.1084/jem.20151159. Epub 2015 Aug 10.
3
Pathogenesis and targeted treatment of skin injury in SLE.SLE 皮肤损伤的发病机制与靶向治疗。
Ther Adv Musculoskelet Dis. 2020 Sep 14;12:1759720X20953336. doi: 10.1177/1759720X20953336. eCollection 2020.
4
TARGETING TARGETED TREATMENT FOR IMMUNE AND NON-IMMUNE KIDNEY DISEASES.针对免疫性和非免疫性肾脏疾病的靶向治疗
Trans Am Clin Climatol Assoc. 2019;130:88-99.
5
Pathogenesis and treatment of autoimmune rheumatic diseases.自身免疫性风湿病的发病机制与治疗。
Curr Opin Rheumatol. 2019 May;31(3):307-315. doi: 10.1097/BOR.0000000000000594.
6
IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion.IFNα 通过依赖 STING 的方式损害 mtDNA 的自噬降解，从而促进 SLE 单核细胞的自身反应性。
Cell Rep. 2018 Oct 23;25(4):921-933.e5. doi: 10.1016/j.celrep.2018.09.001.
7
Calcium/Calmodulin Kinase IV Controls the Function of Both T Cells and Kidney Resident Cells.钙/钙调蛋白激酶 IV 控制 T 细胞和肾脏固有细胞的功能。
Front Immunol. 2018 Oct 1;9:2113. doi: 10.3389/fimmu.2018.02113. eCollection 2018.
8
Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective.人类系统性红斑狼疮的发病机制：细胞视角
Trends Mol Med. 2017 Jul;23(7):615-635. doi: 10.1016/j.molmed.2017.05.006. Epub 2017 Jun 13.
9
Activation of the Mechanistic Target of Rapamycin in SLE: Explosion of Evidence in the Last Five Years.系统性红斑狼疮中雷帕霉素作用机制靶点的激活：过去五年的证据激增
Curr Rheumatol Rep. 2016 Dec;18(12):73. doi: 10.1007/s11926-016-0622-8.
10
Altered dendritic cell functions in autoimmune diseases: distinct and overlapping profiles.自身免疫性疾病中树突状细胞功能的改变：独特而重叠的特征。
Nat Rev Rheumatol. 2016 Dec;12(12):703-715. doi: 10.1038/nrrheum.2016.147. Epub 2016 Sep 22.
Nat Rev Rheumatol. 2015 Nov;11(11):663-9. doi: 10.1038/nrrheum.2015.106. Epub 2015 Aug 4.
4
OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response.OX40配体通过促进滤泡辅助性T细胞反应参与人类狼疮发病机制。
Immunity. 2015 Jun 16;42(6):1159-70. doi: 10.1016/j.immuni.2015.05.012. Epub 2015 Jun 9.
5
T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity.T细胞信号异常导致免疫细胞功能异常和自身免疫。
J Clin Invest. 2015 Jun;125(6):2220-7. doi: 10.1172/JCI78087. Epub 2015 May 11.
6
Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus.CD11c(+)髓样细胞对ICOS共受体的局部激活驱动狼疮中的器官炎症。
Immunity. 2015 Mar 17;42(3):552-65. doi: 10.1016/j.immuni.2015.02.015.
7
Normalization of CD4+ T cell metabolism reverses lupus.CD4+ T细胞代谢的正常化可逆转狼疮。
Sci Transl Med. 2015 Feb 11;7(274):274ra18. doi: 10.1126/scitranslmed.aaa0835.
8
The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells.共抑制受体CTLA-4通过调节滤泡辅助性T细胞、滤泡调节性T细胞和调节性T细胞来控制B细胞反应。
Immunity. 2014 Dec 18;41(6):1026-39. doi: 10.1016/j.immuni.2014.12.005. Epub 2014 Dec 5.
9
Cgnz1 allele confers kidney resistance to damage preventing progression of immune complex-mediated acute lupus glomerulonephritis.Cgnz1 等位基因赋予肾脏对损伤的抗性，防止免疫复合物介导的急性狼疮性肾小球肾炎进展。
J Exp Med. 2013 Oct 21;210(11):2387-401. doi: 10.1084/jem.20130731. Epub 2013 Oct 7.
10
Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys.系统性红斑狼疮患者中扩增的双阴性T细胞产生白细胞介素-17并浸润肾脏。
J Immunol. 2008 Dec 15;181(12):8761-6. doi: 10.4049/jimmunol.181.12.8761.