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丹参干燥根水提取物及其主要成分对大鼠正畸牙齿移动加速作用的研究

The effects of dried root aqueous extract of Salvia miltiorrhiza and its major ingredient in acceleration of orthodontic tooth movement in rat.

作者信息

Xiao Li-Qun, Wang Hong-Tao, Li Yu-Lan, Zeng Qing, Zhou E, Ni Xia, Huan Zhong-Ping

机构信息

Department of Stomatology, The First College of Clinical Medical Science of China Three Gorges University, Yichang Central People's Hospital, Yichang 443003, China.

出版信息

Iran J Basic Med Sci. 2015 Oct;18(10):1044-9.

PMID:26730341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4686576/
Abstract

OBJECTIVES

Salvia miltiorrhiza (SM) is a popular and classic herb in traditional Chineses medicines. The objective is to confirm the effects of aqueous extract of S. miltiorrhiza (ESM) and its main ingredient on the promotion of orthodontic tooth movement and healing of periodontal ligament in rat.

MATERIALS AND METHODS

Male Sprague-Dawley rats (n= 150) were divided into five groups: model control group (0.5 ml/kg phosphate-buffered saline (PBS) injection), ESM group (0.75 g/kg/day of crude drugs) and Danshensu subgroups (250, 500, 750 mg/kg/day of body weight). All rats were administered intramuscularly into the buccal vestibular mucosa of first molar of left maxillary. The indicators such as the moving distance of orthodontic tooth, nuclear factor κB ligand (RANKL) and osteoprotegerin (OPG) expression and osteoclasts were tested.

RESULTS

The expressions of RANKL and OPG in the treatment groups were obviously enhanced compared with control group (P<0.05). The increase rate of OPG expression was slower than that of RANKL. But, RANKL decreased conspicuously after no orthodontic pressure was applied, especially in the treatment groups (Danshengsu high dose group at day 30: 2.17 versus 3.47 of control, P<0.01). ESM groups promoted osteoclasts proliferation in the first 20 days.

CONCLUSION

There is a relationship between RANKL/OPG ratio and the number of osteoclasts. ESM might accelerate periodontal alteration of rat orthodontic tooth via producing more osteoclasts.

摘要

目的

丹参是传统中药中一种常用且经典的草药。目的是证实丹参水提取物（ESM）及其主要成分对促进大鼠正畸牙移动和牙周膜愈合的作用。

材料与方法

将150只雄性Sprague-Dawley大鼠分为五组：模型对照组（注射0.5 ml/kg磷酸盐缓冲盐水（PBS））、ESM组（750 mg/kg/天的生药）和丹参素亚组（250、500、750 mg/kg/天体重）。所有大鼠均通过肌肉注射于左上颌第一磨牙颊侧前庭黏膜。检测正畸牙移动距离、核因子κB配体（RANKL）和骨保护素（OPG）表达以及破骨细胞等指标。

结果

与对照组相比，治疗组RANKL和OPG的表达明显增强（P<0.05）。OPG表达的增加率低于RANKL。但是，在去除正畸力后RANKL显著下降，尤其是在治疗组（丹参素高剂量组在第30天：2.17对对照组的3.47，P<0.01）。ESM组在前20天促进破骨细胞增殖。

结论

RANKL/OPG比值与破骨细胞数量之间存在关联。ESM可能通过产生更多破骨细胞加速大鼠正畸牙的牙周改建。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d6b/4686576/7044c6aa3224/IJBMS-18-1044-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d6b/4686576/d836d8d9bf05/IJBMS-18-1044-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d6b/4686576/54bc19a4e7eb/IJBMS-18-1044-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d6b/4686576/c547b7063cad/IJBMS-18-1044-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d6b/4686576/2a42492500f6/IJBMS-18-1044-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d6b/4686576/51437a3b70b5/IJBMS-18-1044-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d6b/4686576/83def3dd8a09/IJBMS-18-1044-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d6b/4686576/e9d783c43b11/IJBMS-18-1044-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d6b/4686576/e3994eb72b8f/IJBMS-18-1044-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d6b/4686576/7044c6aa3224/IJBMS-18-1044-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d6b/4686576/d836d8d9bf05/IJBMS-18-1044-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d6b/4686576/54bc19a4e7eb/IJBMS-18-1044-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d6b/4686576/c547b7063cad/IJBMS-18-1044-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d6b/4686576/2a42492500f6/IJBMS-18-1044-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d6b/4686576/51437a3b70b5/IJBMS-18-1044-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d6b/4686576/83def3dd8a09/IJBMS-18-1044-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d6b/4686576/e9d783c43b11/IJBMS-18-1044-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d6b/4686576/e3994eb72b8f/IJBMS-18-1044-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d6b/4686576/7044c6aa3224/IJBMS-18-1044-g009.jpg

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