Flores Sebastián, Avilés Carolina, Rada Gabriel
Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile. Address: Facultad de Medicina, Pontificia Universidad Católica de Chile, Lira 63, Santiago Centro, Chile. Email:
Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile.
Medwave. 2015 Dec 7;15 Suppl 3:e6330. doi: 10.5867/medwave.2015.6330.
Upper gastrointestinal bleeding constitutes a medical-surgical emergency given its important associated morbidity and mortality. The antifibrinolytic tranexamic acid might help stopping bleeding, but controversy remains about its role in this setting. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified five systematic reviews including eight randomized trials. We combined the evidence using meta-analysis and generated a summary of findings table following the GRADE approach. We concluded tranexamic acid probably decreases rebleeding and mortality, without increasing thromboembolic adverse effects in patients with upper gastrointestinal bleeding.
上消化道出血因其重要的相关发病率和死亡率而构成内科-外科急症。抗纤维蛋白溶解剂氨甲环酸可能有助于止血，但在这种情况下其作用仍存在争议。在由筛选30个数据库维护的Epistemonikos数据库中进行检索，我们识别出五项系统评价，包括八项随机试验。我们使用荟萃分析合并证据，并按照GRADE方法生成了结果总结表。我们得出结论，氨甲环酸可能会降低上消化道出血患者的再出血率和死亡率，且不会增加血栓栓塞性不良反应。
