Department of Chemistry, University of Minnesota , 207 Pleasant Street, SE, Minneapolis, Minnesota 55455, United States.
Org Lett. 2016 Jan 15;18(2):188-91. doi: 10.1021/acs.orglett.5b03213. Epub 2016 Jan 5.
A new class of readily prepared thiourea catalysts with one or more positively charged centers and no new hydrogen-bonding sites are exploited in several bond-forming reactions and are orders of magnitude more reactive than Schreiner's thiourea. These findings provide the basis for a new strategy for activating hydrogen-bond catalysts.
一类新型的、制备简便的硫脲催化剂被开发出来，这些催化剂带有一个或多个正电荷中心且不含新的氢键供体或受体。该类催化剂在多种成键反应中都有很好的应用，其反应活性比 Schreiner 硫脲高几个数量级。这些发现为激活氢键催化剂提供了新的策略。
