Zupanets I A, Shebeko S K, Popov O S, Shalamay A S
National University of Pharmacy, 27 Pushkinska Str., Kharkiv, 61057, Ukraine.
PJSC SIC "Borshchahivskiy CPP", Kyiv, Ukraine.
Inflammopharmacology. 2016 Feb;24(1):53-7. doi: 10.1007/s10787-015-0258-8. Epub 2016 Jan 5.
The aim of the present study was to investigate anti-inflammatory activity of Diclocor in the setting of collagen-induced osteoarthritis in rats in comparison with its active monocomponents-diclofenac sodium and quercetin.
The study was conducted on the model of collagen-induced osteoarthritis and included measurement of sialic acids, glycoproteins, C-reactive protein, prostaglandin E2, 6-keto-prostaglandin F1α, thromboxane B2, and leukotriene B4. Lastly, morphologic study with morphometry was also performed.
Diclocor is superior to quercetin and diclofenac sodium by the degree of pharmacological effect on some of the studied parameters. The differences between the values were statistically significant.
Diclocor is a promising corrector of inflammatory and destructive joint diseases. Owing to the presence of both diclofenac sodium and quercetin in its composition, Diclocor exhibits a complex mechanism of anti-inflammatory action affecting cyclooxygenase and lipoxygenase ways of arachidonic acid biotransformation.
本研究旨在比较双氯可（Diclocor）与其活性单一组分双氯芬酸钠和槲皮素，在大鼠胶原诱导性骨关节炎模型中的抗炎活性。
本研究采用胶原诱导性骨关节炎模型，检测指标包括唾液酸、糖蛋白、C反应蛋白、前列腺素E2、6-酮-前列腺素F1α、血栓素B2和白三烯B4。最后，还进行了形态学研究及形态测量。
在对部分研究参数的药理作用程度上，双氯可优于槲皮素和双氯芬酸钠。这些数值之间的差异具有统计学意义。
双氯可是一种有前景的炎症性和破坏性关节疾病的矫正药物。由于其成分中同时含有双氯芬酸钠和槲皮素，双氯可展现出影响花生四烯酸生物转化的环氧合酶和脂氧合酶途径的复杂抗炎作用机制。
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