Eldor A, Vlodavsky I, Deutsch V, Levine R F
Baillieres Clin Haematol. 1989 Jul;2(3):543-68. doi: 10.1016/s0950-3536(89)80033-2.
More than a hundred years have passed since platelets were recognized as cells and their haemostatic functions discovered. However, the process of platelet production is still not understood. The location, the mechanism and the regulation of thrombopoiesis remain elusive. Megakaryocytes are known to be the source of platelets. Investigations of megakaryocytes have revealed their normal functions and some of the abnormalities present in various diseases which affect platelets. In recent years, new techniques of cell isolation and tissue culture have been developed and have made possible advances in characterizing megakaryocyte precursors and differentiation. The primary function of megakaryocytes is to synthesize and assemble platelet components and organelles. Although debated for a long time, new data seems to indicate that the lung may be a central locus of platelet production. The new techniques for megakaryocyte investigations have barely begun to be of use in the study of abnormal platelet production in disease.
自血小板被确认为细胞并发现其止血功能以来，已经过去了一百多年。然而，血小板生成的过程仍未被理解。血小板生成的位置、机制和调节仍然难以捉摸。已知巨核细胞是血小板的来源。对巨核细胞的研究揭示了它们的正常功能以及各种影响血小板的疾病中存在的一些异常情况。近年来，细胞分离和组织培养的新技术得到了发展，并使得在表征巨核细胞前体和分化方面取得进展成为可能。巨核细胞的主要功能是合成和组装血小板成分及细胞器。尽管长期以来一直存在争议，但新数据似乎表明肺可能是血小板生成的中心场所。用于巨核细胞研究的新技术在疾病中异常血小板生成的研究中几乎尚未开始发挥作用。
