Ko Eun-Yi, Moon Aree
College of Pharmacy, Duksung Women's University, Seoul, Korea.
J Cancer Prev. 2015 Dec;20(4):223-31. doi: 10.15430/JCP.2015.20.4.223. Epub 2015 Dec 30.
Breast cancer is the primary cause of cancer death in women. Although current therapies have shown some promise against breast cancer, there is still no effective cure for the majority of patients in the advanced stages of breast cancer. Development of effective agents to slow, reduce, or reverse the incidence of breast cancer in high-risk women is necessary. Chemoprevention of breast cancer by natural products is advantageous, as these compounds have few side effects and low toxicity compared to synthetic compounds. In the present review, we summarize natural products which exert chemopreventive activities against breast cancer, such as curcumin, sauchinone, lycopene, denbinobin, genipin, capsaicin, and ursolic acid. This review examines the current knowledge about natural compounds and their mechanisms that underlie breast cancer chemopreventive activity both in vitro and in vivo. The present review may provide information on the use of these compounds for the prevention of breast cancer.
乳腺癌是女性癌症死亡的主要原因。尽管目前的治疗方法已显示出对乳腺癌有一定疗效，但对于大多数处于晚期乳腺癌的患者来说，仍然没有有效的治愈方法。开发有效的药物来减缓、降低或逆转高危女性患乳腺癌的几率是必要的。天然产物对乳腺癌的化学预防具有优势，因为与合成化合物相比，这些化合物副作用少且毒性低。在本综述中，我们总结了对乳腺癌具有化学预防活性的天然产物，如姜黄素、朝鲜蓟素、番茄红素、滇紫草素、京尼平、辣椒素和熊果酸。本综述探讨了关于天然化合物及其在体外和体内对乳腺癌化学预防活性潜在机制的现有知识。本综述可能会提供有关使用这些化合物预防乳腺癌的信息。
