一种从八角茴香果实中提取的新型黄烷酸。
A new flavane acid from the fruits of Illicium verum.
作者信息
Wu Liang-Deng, Xiong Chun-Lan, Chen Zi-Zhan, He Rui-Jie, Zhang Yan-Jun, Huang Yan, Deng Sheng-Ping, Yang Rui-Yun, Li Jun
机构信息
a Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), School of Environment and Resource , Guangxi Normal University , Guilin , P. R. China.
b Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Ministry of Education of China) , Guilin , P. R. China.
出版信息
Nat Prod Res. 2016 Jul;30(14):1585-90. doi: 10.1080/14786419.2015.1120726. Epub 2016 Jan 6.
A new compound, illiciumflavane acid (1), along with 13 known compounds (2-14), were isolated from the fruits of Illicium verum Hook. F. Their structures were elucidated through various spectroscopic methods, including 1D NMR ((1)H NMR, (13)C NMR), 2D NMR (HMQC, HMBC and NOESY) and HRMS. The stereochemistry at the chiral centres was determined using CD spectrum as well as analyses of coupling constants and optical rotation data. Cytotoxicity evaluation of four compounds showed that illiciumflavane acid and (E)-1,2-bis(4-methoxyphenyl)ethene exhibited potential against A549 activities with IC50 values of 4.63 μM and 9.17 μM, respectively.
从八角茴香的果实中分离出一种新化合物——八角黄烷酸（1）以及13种已知化合物（2 - 14）。通过各种光谱方法对其结构进行了阐明，包括一维核磁共振（¹H NMR、¹³C NMR）、二维核磁共振（HMQC、HMBC和NOESY）以及高分辨质谱。利用圆二色光谱以及偶合常数和旋光数据的分析确定了手性中心的立体化学。对四种化合物的细胞毒性评估表明，八角黄烷酸和（E）-1,2-双（4-甲氧基苯基）乙烯对A549细胞显示出潜在活性，其IC50值分别为4.63 μM和9.17 μM。
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