八角茴香果实成分的DNA拓扑异构酶抑制活性
DNA Topoisomerase Inhibitory Activity of Constituents from the Fruits of Illicium verum.
作者信息
Kim Tae In, Shin Bora, Kim Geum Jin, Choi Hyukjae, Lee Chong Soon, Woo Mi Hee, Oh Dong-Chan, Son Jong Keun
机构信息
College of Pharmacy, Yeungnam University.
College of Pharmacy, Seoul National University.
出版信息
Chem Pharm Bull (Tokyo). 2017 Dec 1;65(12):1179-1184. doi: 10.1248/cpb.c17-00466. Epub 2017 Sep 26.
Three new compounds, a sesquilignan (1) and two glucosylated phenylpropanoids (2, 3), and seven known compounds (4-10), were isolated from the fruits of Illicium verum HOOK. FIL. (Illiciaceae). The structures of 1-3 were determined based on one and two dimensional (1D- and 2D-) NMR data and electronic circular dichroism (ECD) spectra analyses. Compounds 3, 5, 6, and 8-10 exhibited potent inhibitory activities against topoisomerase II with IC values of 54.6, 25.5, 17.9, 12.1, 0.3 and 1.0 µM, respectively, compared to etoposide, the positive control, with an IC of 43.8 µM.
从八角茴香（八角科）的果实中分离出三种新化合物，一种倍半木脂素（1）和两种糖基化苯丙素类化合物（2, 3），以及七种已知化合物（4 - 10）。基于一维和二维（1D - 和2D -）核磁共振数据以及电子圆二色光谱（ECD）分析确定了1 - 3的结构。与阳性对照依托泊苷（IC为43.8 μM）相比，化合物3、5、6以及8 - 10对拓扑异构酶II表现出强效抑制活性，IC值分别为54.6、25.5、17.9、12.1、0.3和1.0 μM。
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