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揭示体内炎性小体活性。

Illuminating inflammasome activity in vivo.

作者信息

Hickman Heather D

机构信息

Laboratory of Viral Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

出版信息

Nat Med. 2016 Jan;22(1):22-3. doi: 10.1038/nm.4026.

DOI:10.1038/nm.4026
PMID:26735405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6369000/
Abstract

Sentinel macrophages in the lymph node provide a first line of defense against invading viruses. A new study visualizes inflammasome activation in virally infected nodal macrophages in mice and shows that this activation augments both innate and adaptive immunity.

摘要

淋巴结中的哨兵巨噬细胞为抵御入侵病毒提供了第一道防线。一项新研究观察到了小鼠病毒感染的淋巴结巨噬细胞中的炎性小体激活,并表明这种激活增强了先天性免疫和适应性免疫。

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Illuminating inflammasome activity in vivo.揭示体内炎性小体活性。
Nat Med. 2016 Jan;22(1):22-3. doi: 10.1038/nm.4026.
2
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Aminated nanomicelles as a designer vaccine adjuvant to trigger inflammasomes and multiple arms of the innate immune response in lymph nodes.胺化纳米胶束作为一种定制疫苗佐剂,可触发炎性小体和淋巴结中固有免疫反应的多个分支。
Int J Nanomedicine. 2017 Oct 12;12:7501-7517. doi: 10.2147/IJN.S144623. eCollection 2017.

本文引用的文献

1
In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity.体内成像研究炎症小体激活揭示了被膜下巨噬细胞爆发反应,该反应可动员先天和适应性免疫。
Nat Med. 2016 Jan;22(1):64-71. doi: 10.1038/nm.4016. Epub 2015 Dec 21.
2
Pyroptotic cell death defends against intracellular pathogens.细胞焦亡可抵御细胞内病原体。
Immunol Rev. 2015 May;265(1):130-42. doi: 10.1111/imr.12287.
3
Host response. Inflammation-induced disruption of SCS macrophages impairs B cell responses to secondary infection.
宿主反应。炎症引起的 SCS 巨噬细胞破坏,会损害 B 细胞对二次感染的反应。
Science. 2015 Feb 6;347(6222):667-72. doi: 10.1126/science.aaa1300.
4
Strategically localized dendritic cells promote rapid T cell responses to lymph-borne particulate antigens.策略性定位树突状细胞促进淋巴源性颗粒抗原引发的快速 T 细胞应答。
Immunity. 2015 Jan 20;42(1):172-85. doi: 10.1016/j.immuni.2014.12.024. Epub 2014 Dec 27.
5
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.衔接子 ASC 具有传播炎症的细胞外和“朊病毒样”活性。
Nat Immunol. 2014 Aug;15(8):727-37. doi: 10.1038/ni.2913. Epub 2014 Jun 22.
6
Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation.牛痘病毒 F1L 蛋白通过抑制炎症小体激活促进毒力。
Proc Natl Acad Sci U S A. 2013 May 7;110(19):7808-13. doi: 10.1073/pnas.1215995110. Epub 2013 Apr 19.
7
Deletion of the viral anti-apoptotic gene F1L in the HIV/AIDS vaccine candidate MVA-C enhances immune responses against HIV-1 antigens.在 HIV/AIDS 候选疫苗 MVA-C 中删除病毒抗凋亡基因 F1L 可增强针对 HIV-1 抗原的免疫应答。
PLoS One. 2012;7(10):e48524. doi: 10.1371/journal.pone.0048524. Epub 2012 Oct 31.
8
A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread.淋巴结中空间组织的多细胞先天免疫反应限制了病原体在全身的传播。
Cell. 2012 Sep 14;150(6):1235-48. doi: 10.1016/j.cell.2012.07.021.
9
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.AIM2 炎性小体对于宿主防御细胞质细菌和 DNA 病毒至关重要。
Nat Immunol. 2010 May;11(5):395-402. doi: 10.1038/ni.1864. Epub 2010 Mar 28.
10
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.AIM2可识别胞质双链DNA,并与ASC形成激活半胱天冬酶-1的炎性小体。
Nature. 2009 Mar 26;458(7237):514-8. doi: 10.1038/nature07725. Epub 2009 Jan 21.