大肠杆菌诱发的复发性溶血尿毒综合征
Recurrent Hemolytic and Uremic Syndrome Induced by Escherichia Coli.
作者信息
Commereuc Morgane, Weill Francois-Xavier, Loukiadis Estelle, Gouali Malika, Gleizal Audrey, Kormann Raphaël, Ridel Christophe, Frémeaux-Bacchi Véronique, Rondeau Eric, Hertig Alexandre
机构信息
From the APHP, Hôpital Tenon (MC, RK, CR, ER, AH), Urgences Néphrologiques et Transplantation Rénale, Institut Pasteur (F-XW, MG), Unité des Bactéries Pathogènes Entériques, Centre National de Référence des E coli et Shigella, Paris, VetAgro Sup (EL, AG), Campus vétérinaire de Lyon, Laboratoire d'études des microorganismes alimentaires pathogènes (LMAP), Laboratoire National de Référence pour les E coli y compris les E coli producteurs de Shiga-toxines (LNR STEC), Marcy L'Etoile, Service d'Immunologie, Hôpital Européen Georges Pompidou (VF-B); and UPMC Sorbonne Université Paris 06 (ER, AH), Paris, France.
出版信息
Medicine (Baltimore). 2016 Jan;95(1):e2050. doi: 10.1097/MD.0000000000002050.
A widespread belief is that typical hemolytic and uremic syndrome (HUS) does not recur. We report the case of a patient infected twice with raw milk taken from his own cow and containing a Shiga toxin-producing Escherichia coli O174:H21 that induced recurrent HUS causing severe renal and cerebral disorders. A genomic comparison of the human and bovine Shiga toxin-producing Escherichia coli O174:H21 isolates revealed that they were identical. Typical HUS may recur. Since milk from this animal was occasionally distributed locally, thereby posing a serious threat for the whole village, this particular cow was destroyed.
一种普遍的看法是典型的溶血尿毒综合征（HUS）不会复发。我们报告了一例患者的病例，该患者两次感染了取自自家奶牛的生牛奶，其中含有产志贺毒素的大肠杆菌O174:H21，引发了复发性HUS，导致严重的肾脏和脑部疾病。对人类和牛源产志贺毒素的大肠杆菌O174:H21分离株进行基因组比较后发现它们是相同的。典型的HUS可能会复发。由于这头奶牛的牛奶偶尔会在当地分发，从而对整个村庄构成严重威胁，这头特殊的奶牛被销毁了。
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