Christophers E, Schröder J M, Mrowietz U
Department of Dermatology, University of Kiel, FRG.
Dermatologica. 1989;179 Suppl 1:9-15. doi: 10.1159/000248440.
Migration of polymorphonuclear leukocytes (PMN) into the upper layers of involved epidermis represents a characteristic feature of psoriasis. By analysis of psoriatic scale material we were able to identify two potent proinflammatory peptides, which are present in the upper epidermis from psoriatic lesions. Both factors (C5ades arg and NAP) show strong chemotactic activity for human neutrophils in vitro as well as in vivo. Whereas C5ades arg is a known mediator activated by either alternative or classical activation of the complement cascade, NAP represents a newly detected peptide with a molecular weight of 8,000 daltons which is produced by a variety of cells participating in the psoriatic tissue reaction.
多形核白细胞（PMN）迁移至受累表皮上层是银屑病的一个特征性表现。通过对银屑病鳞屑材料的分析，我们能够鉴定出两种强效促炎肽，它们存在于银屑病皮损的上层表皮中。这两种因子（C5ades arg和NAP）在体外和体内对人中性粒细胞均表现出强烈的趋化活性。C5ades arg是补体级联反应的替代激活或经典激活所激活的一种已知介质，而NAP是一种新发现的分子量为8000道尔顿的肽，由参与银屑病组织反应的多种细胞产生。
