Sticherling M, Bornscheuer E, Schröder J M, Christophers E
Department of Dermatology, University of Kiel, Federal Republic of Germany.
Arch Dermatol Res. 1992;284(2):82-5. doi: 10.1007/BF00373374.
The neutrophil activating peptide NAP-1/IL-8 has in the past been shown to be secreted by diverse cell-types involved in inflammatory processes. Furthermore, potent biological effects on both neutrophilic granulocytes and lymphocytes enforce its role in inflammation. Recently, immunohistochemical studies using monoclonal anti-NAP-1/IL-8 antibodies have been performed on dermal inflammatory conditions like psoriasis vulgaris. These have demonstrated epidermal IL-8 immunoreactivity in a pattern inversely related to the degree of inflammatory infiltration. Based on these results, in the present study biopsies from patients with contact eczema as well as atopic dermatitis were examined. The same patterns of immunoreactivity were found with either homogeneous epidermal staining, focally negative staining or overall decreased or even absent staining. As in psoriasis, these patterns were related to the degree of inflammatory infiltration. These results prove NAP-1/IL-8 to be involved not only in psoriasis vulgaris, but more likely to be a marker of different inflammatory processes. Future work will have to examine the kinetics as well as stimuli causing these effect.
中性粒细胞激活肽NAP-1/IL-8过去已被证明可由参与炎症过程的多种细胞类型分泌。此外，它对嗜中性粒细胞和淋巴细胞具有强大的生物学效应，这进一步证实了其在炎症中的作用。最近，已经使用抗NAP-1/IL-8单克隆抗体对诸如寻常型银屑病等皮肤炎症性疾病进行了免疫组织化学研究。这些研究表明，表皮IL-8免疫反应性的模式与炎症浸润程度呈负相关。基于这些结果，在本研究中，对接触性湿疹和特应性皮炎患者的活检组织进行了检查。发现了相同的免疫反应性模式，即表皮染色均匀、局灶性阴性染色或整体染色减少甚至缺失。与银屑病一样，这些模式与炎症浸润程度有关。这些结果证明NAP-1/IL-8不仅参与寻常型银屑病，更有可能是不同炎症过程的标志物。未来的工作将必须研究导致这些效应的动力学以及刺激因素。
