共生细菌调节肿瘤微环境。
Commensal bacteria modulate the tumor microenvironment.
作者信息
Poutahidis Theofilos, Erdman Susan E
机构信息
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Laboratory of Pathology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Greece 54124.
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
出版信息
Cancer Lett. 2016 Sep 28;380(1):356-8. doi: 10.1016/j.canlet.2015.12.028. Epub 2015 Dec 29.
Abstract
It has been recently shown that gut microbes modulate whole host immune and hormonal factors impacting the fate of distant preneoplastic lesions toward malignancy or regression. This raises the possibility that the tumor microenvironment interacts with broader systemic microbial-immune networks. These accumulated findings suggest novel therapeutic opportunities for holobiont engineering in emerging tumor microenvironments.
摘要
最近的研究表明，肠道微生物可调节整个宿主的免疫和激素因子，影响远处癌前病变向恶性或消退的转归。这增加了肿瘤微环境与更广泛的全身微生物-免疫网络相互作用的可能性。这些累积的发现为新兴肿瘤微环境中的全生物工程提供了新的治疗机会。
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