Negrut Roxana Loriana, Cote Adrian, Maghiar Adrian Marius
Department Medicine, Doctoral School of Biomedical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.
County Clinical Emergency Hospital Bihor, 410087 Oradea, Romania.
Microorganisms. 2023 Jun 15;11(6):1586. doi: 10.3390/microorganisms11061586.
There is growing evidence indicating that the oral microbiota, specifically certain periodontopathogens such as , may play a role in the development of colorectal cancer and that it could potentially be used as a biomarker for diagnosing colorectal cancer (CRC). The question beneath this systematic review is whether the development or progression of colorectal cancer can be attributed to the presence of certain oral bacteria, which could be used for discovering non-invasive biomarkers for CRC. This review aims to give an overview of the actual status of published studies regarding the oral pathogens related to colorectal cancer and assess the effectiveness of the oral microbiome derived biomarkers. A systematic literature search was performed using four databases, Web of Science, Scopus, PubMed, and Science Direct, on the 3rd and 4th of March 2023. The studies that did not have matching inclusion/exclusion criteria were winnowed out. A total of fourteen studies were included. The risk of bias was performed by using QUADAS-2. After assessing the studies, the general conclusion is that oral microbiota-based biomarkers can become a promising non-invasive tool for detecting CRC, but further research is needed in order to determine the mechanisms of oral dysbiosis in colorectal carcinogenesis.
越来越多的证据表明，口腔微生物群，特别是某些牙周病原体，如……，可能在结直肠癌的发生发展中起作用，并且有可能被用作诊断结直肠癌（CRC）的生物标志物。本系统评价背后的问题是，结直肠癌的发生或进展是否可归因于某些口腔细菌的存在，而这些细菌可用于发现CRC的非侵入性生物标志物。本综述旨在概述已发表的关于与结直肠癌相关的口腔病原体的研究现状，并评估源自口腔微生物群的生物标志物的有效性。2023年3月3日和4日，使用Web of Science、Scopus、PubMed和Science Direct这四个数据库进行了系统的文献检索。剔除了不符合纳入/排除标准的研究。共纳入14项研究。使用QUADAS-2进行偏倚风险评估。在对这些研究进行评估后，总体结论是，基于口腔微生物群的生物标志物可以成为一种有前景的检测CRC的非侵入性工具，但需要进一步研究以确定口腔生态失调在结直肠癌发生中的机制。
