CO17-1A和B72.3在胰腺良恶性疾病中的反应性。

Reactivity of CO17-1A and B72.3 in benign and malignant pancreatic diseases.

作者信息

Takiyama Y, Tempero M A, Takasaki H, Onda M, Tsuchiya R, Büchler M, Ness M, Colcher D, Schlom J, Pour P M

机构信息

The Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha 68105.

出版信息

Hum Pathol. 1989 Sep;20(9):832-8. doi: 10.1016/0046-8177(89)90093-2.

DOI:10.1016/0046-8177(89)90093-2

PMID:2673979

Abstract

The immunoreactivity of two monoclonal antibodies, CO17-1A (recognizing 17-1A antigen) and B72.3 (recognizing TAG-72), was examined in pancreatic tissues from individuals without pancreatic disease and from those with benign and malignant pancreatic disease. 17-1A antigen was found in all cells in the normal tissue, whereas TAG-72 was present in the duct cells in only one case. Both antigens were present in benign diseases; however, in some cells and in some conditions, TAG-72 was significantly less common (P less than .01 to .001) than 17-1A antigen. In pancreatic cancer, 17-1A antigen was present in 87% of cases and TAG-72 antigen was present in 92% of cases. The results indicate that B72.3 is more specific to pancreatic cancer than C017-1A.

摘要

在无胰腺疾病个体以及患有胰腺良性和恶性疾病个体的胰腺组织中，检测了两种单克隆抗体CO17 - 1A（识别17 - 1A抗原）和B72.3（识别TAG - 72）的免疫反应性。正常组织中的所有细胞均发现有17 - 1A抗原，而仅在1例的导管细胞中发现有TAG - 72。两种抗原在良性疾病中均存在；然而，在某些细胞和某些情况下，TAG - 72比17 - 1A抗原明显少见（P小于0.01至0.001）。在胰腺癌中，87%的病例存在17 - 1A抗原，92%的病例存在TAG - 72抗原。结果表明，B72.3对胰腺癌的特异性高于C017 - 1A。