猫后睾吸虫：生物学、流行病学及致癌潜力
The liver fluke Opisthorchis felineus: biology, epidemiology and carcinogenic potential.
作者信息
Pakharukova Mariya Y, Mordvinov Viatcheslav A
机构信息
Laboratory of Molecular Mechanisms of Pathological Processes, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia.
Laboratory of Molecular Mechanisms of Pathological Processes, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia Laboratory of Pharmacokinetic and Drugs Metabolism, Institute of Molecular Biology and Biophysics Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, 630060, Russia
出版信息
Trans R Soc Trop Med Hyg. 2016 Jan;110(1):28-36. doi: 10.1093/trstmh/trv085.
The liver fluke Opisthorchis felineus is a member of the triad of epidemiologically important liver fluke species belonging to the family Opisthorchiidae and the major agent causing opisthorchiasis over a vast territory, covering Russia, Kazakhstan and several European countries. The similarity between the diseases caused by O. felineus and other liver flukes, O. viverrini and Clonorchis sinensis, in clinical manifestations and course suggests that the scenarios of their development and, possibly, complications have much in common. The International Agency for Research on Cancer classified O. viverrini and C. sinensis as group 1 agents and the major factors inducing cholangiocarcinoma in endemic regions. However, a carcinogenic potential of O. felineus is poorly studied. This review characterizes O. felineus, briefs the epidemiological situation in Western Siberia, the world's largest opisthorchiasis focus, and assesses the carcinogenic potential of this liver fluke. The review is based on a comprehensive analysis of the published medical data on opisthorchiasis and its complications in Western Siberia. Results of performed analysis reflect the actual epidemiological situation in opisthorchiasis focus and suggest an association of this disease with bile duct cancer.
猫后睾吸虫是后睾科中在流行病学上具有重要意义的三种肝吸虫之一，是俄罗斯、哈萨克斯坦及几个欧洲国家广大地区引起后睾吸虫病的主要病原体。猫后睾吸虫与其他肝吸虫，如 viverrini 后睾吸虫和华支睾吸虫，在临床表现和病程方面存在相似性，这表明它们的发育情况以及可能的并发症有许多共同之处。国际癌症研究机构将 viverrini 后睾吸虫和华支睾吸虫列为 1 类致癌物，是流行地区诱发胆管癌的主要因素。然而，猫后睾吸虫的致癌潜力研究较少。本综述对猫后睾吸虫进行了描述，简述了世界上最大的后睾吸虫病疫源地西西伯利亚的流行病学情况，并评估了这种肝吸虫的致癌潜力。该综述基于对西西伯利亚已发表的关于后睾吸虫病及其并发症的医学数据的全面分析。所进行的分析结果反映了后睾吸虫病疫源地的实际流行病学情况，并表明这种疾病与胆管癌有关。
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