Klinger K, Zhang X, Rheda F, Gerber P, Decurtins M, Uhlschmid G, Häcki W, Stamm B, Largiadèr F
Helv Chir Acta. 1989 Jun;56(1-2):189-93.
Pancreatic transplantation requires an effective method to manage exocrine secretion. A new technique to eliminate the exocrine function of the pancreas by obstruction of the duct with polyurethane was investigated in terms of function, outcome and morphology. Polyurethane is an alcoholic solution of block copolymers with the property of polymerizing within 5-10 min. In this study the in-situ pancreatic tail model in dogs was utilized, the pancreatic duct was cannulated and injected with 2-3 ml of polyurethane. As a result, complete atrophy and fibrosclerosis of the exocrine tissue was obtained leaving islets well vascularized and functioning for the entire experimental periods. All animals remained normoglycemic and showed normal K-values. Amylase levels were found to be maximally elevated at 24 h and returned to normal within 2 weeks after duct occlusion. Insulin, glucagon and somatostatin levels remained normal. Because of its ability to effect a complete occlusion of the pancreatic ducts with subsequent atrophy of the exocrine gland and without notable disturbance of endocrine function, we feel that polyurethane solution is superior to previously used materials for this purpose.
胰腺移植需要一种有效的方法来处理外分泌。一种通过用聚氨酯阻塞导管来消除胰腺外分泌功能的新技术，从功能、结果和形态学方面进行了研究。聚氨酯是一种嵌段共聚物的醇溶液，具有在5至10分钟内聚合的特性。在本研究中，使用了犬原位胰尾模型，将胰管插管并注入2至3毫升聚氨酯。结果，外分泌组织完全萎缩并发生纤维硬化，而胰岛在整个实验期间血管化良好且功能正常。所有动物均保持血糖正常，K值也正常。发现淀粉酶水平在24小时时最高升高，并在导管闭塞后2周内恢复正常。胰岛素、胰高血糖素和生长抑素水平保持正常。由于其能够完全阻塞胰管，随后外分泌腺萎缩，且不会对内分泌功能造成明显干扰，我们认为聚氨酯溶液在这方面优于先前使用的材料。
