Rotaru Maria, Nati Angelica-Elena, Avrămoiu Ioan, Grosu Florin, Mălăescu Gheorghe Dan
Department of Dermatology, "Victor Papilian" Faculty of Medicine, "Lucian Blaga" University of Sibiu, University Emergency Hospital of Sibiu, Romania;
Rom J Morphol Embryol. 2015;56(4):1467-72.
The use of dermatoscopy increases melanocytic nevi diagnostic accuracy, and is important for dermoscopic monitoring of atypical lesions, allowing to find significant changes in the earliest stage. Dermoscopic diagnosis of melanocytic nevi type in a group of patients and their follow-up with the assessment of changes occurred during dermoscopic monitoring. Dermoscopically, we followed the nevic size and pattern, the color and pigment distribution. Follow-up visits were scheduled depending on the type of the melanocytic lesions and the patient's compliance. The nevi that have shown significant dermoscopic changes were excised and histopathologically examined. The study was performed on a group of 92 patients, mostly females (56.5%), mean age of 29.1 years. Of the total of 1544 melanocytic nevi examined, 27.4% were atypical and 72.6% common nevi. The average dermoscopic examination interval was 14.1 months. During monitoring, 35.5% atypical nevi and 22.5% common nevi have modified, especially changes in pigmentation and color (31% atypical nevi and 9.9% common nevi) and the appearance of new dermoscopic structures (12.7% atypical nevi and common nevi 8.5%). Of the total nevi monitored, 3% showed significant changes and were excised and examined pathologically, without diagnose of any malignant transformation. In our study, dermoscopic changes appeared in atypical as well as in common nevi. The dermoscopic monitoring of melanocytic-pigmented lesions remains an accessible method of assessment the evolution of nevi and can reduce the risk of appearance of malignant melanoma in the general population.
皮肤镜检查的应用提高了黑素细胞痣的诊断准确性，对于非典型性病变的皮肤镜监测很重要，能够在最早阶段发现显著变化。对一组患者的黑素细胞痣类型进行皮肤镜诊断，并在皮肤镜监测期间评估变化情况以进行随访。在皮肤镜下，我们观察痣的大小和形态、颜色及色素分布。根据黑素细胞病变的类型和患者的依从性安排随访。对显示出显著皮肤镜变化的痣进行切除并做组织病理学检查。该研究对一组92例患者进行，其中大多数为女性（56.5%），平均年龄29.1岁。在总共检查的1544个黑素细胞痣中，27.4%为非典型性痣，72.6%为普通痣。皮肤镜检查的平均间隔时间为14.1个月。在监测期间，35.5%的非典型性痣和22.5%的普通痣发生了改变，尤其是色素沉着和颜色的变化（非典型性痣为31%，普通痣为9.9%）以及新皮肤镜结构的出现（非典型性痣为该研究对一组92例患者进行，其中大多数为女性（56.5%），平均年龄29.1岁。在总共检查的1544个黑素细胞痣中，27.4%为非典型性痣，72.6%为普通痣。皮肤镜检查的平均间隔时间为14.1个月。在监测期间，35.5%的非典型性痣和22.5%的普通痣发生了改变，尤其是色素沉着和颜色的变化（非典型性痣为31%，普通痣为9.9%）以及新皮肤镜结构的出现（非典型性痣为12.7%，普通痣为8.5%）。在所有监测的痣中，3%显示出显著变化并被切除及进行病理检查，未诊断出任何恶性转化。在我们的研究中，非典型性痣和普通痣均出现了皮肤镜变化。对黑素细胞色素沉着性病变的皮肤镜监测仍然是一种评估痣演变的可行方法，并且可以降低普通人群中恶性黑色素瘤出现的风险。 12.7%，普通痣为8.5%）。在所有监测的痣中，3%显示出显著变化并被切除及进行病理检查，未诊断出任何恶性转化。在我们的研究中，非典型性痣和普通痣均出现了皮肤镜变化。对黑素细胞色素沉着性病变的皮肤镜监测仍然是一种评估痣演变的可行方法，并且可以降低普通人群中恶性黑色素瘤出现的风险。
