Fechete Oana, Ungureanu Loredana, Șenilă Simona, Vornicescu Daniela, Dănescu Sorina, Vasilovici Alina, Candrea Elisabeta, Vesa Ștefan Cristian, Cosgarea Rodica
Department of Dermatology, Toxicology and Clinical Pharmacology, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania.
Department of Pharmacology, Toxicology and Clinical Pharmacology, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania.
Oncol Lett. 2019 May;17(5):4139-4144. doi: 10.3892/ol.2018.9737. Epub 2018 Nov 19.
In contrast to Western Europe, in Central and Eastern Europe reports show higher rates of advanced melanoma and lower survival. Our aim was to document and compare melanoma risk factors and skin health behaviour in patients diagnosed with melanoma and people not affected by this disease in a large medical university centre from Romania (Cluj-Napoca). Two hundred and forty-seven melanoma patients followed-up in the Department of Dermatology at the Cluj-Napoca Emergency County Hospital and 956 people not affected by melanoma completed a paper-based questionnaire regarding melanoma risk factors, risk behaviour and self-protecting measures, after giving informed consent. People with melanoma had significantly higher personal risk and protective behaviour, and lower risk behaviour than those not affected. Although our data suggest that melanoma patients are better educated about how to avoid a second primary melanoma, our results are concerning when compared with studies from other countries. The low incidence of self and clinical skin-examination together with the relatively low percentage of participants which would consult a doctor in the case of new/changing mole could be one of the explanations for the late diagnosis of melanoma in the studied population. According to our findings, there is an urgent need for population health campaigns regarding not only primary but also secondary melanoma prevention.
与西欧相比，中欧和东欧的报告显示晚期黑色素瘤发病率更高，生存率更低。我们的目的是记录并比较罗马尼亚克鲁日-纳波卡市一家大型医科大学中心诊断为黑色素瘤的患者和未受此病影响的人群中黑色素瘤的危险因素及皮肤健康行为。在获得知情同意后，克鲁日-纳波卡市急诊县医院皮肤科随访的247例黑色素瘤患者和956例未患黑色素瘤的人完成了一份关于黑色素瘤危险因素、风险行为和自我保护措施的纸质问卷。与未患病者相比，黑色素瘤患者的个人风险和保护行为显著更高，风险行为更低。虽然我们的数据表明黑色素瘤患者在如何避免发生第二原发性黑色素瘤方面接受了更好的教育，但与其他国家的研究相比，我们的结果令人担忧。自我皮肤检查和临床皮肤检查的低发生率，以及在出现新痣或痣变化时会咨询医生的参与者比例相对较低，可能是所研究人群中黑色素瘤诊断较晚的原因之一。根据我们的研究结果，迫切需要开展不仅针对原发性黑色素瘤预防，也针对继发性黑色素瘤预防的人群健康运动。
