漂浮（致病）岛：基因组中的“甜点”
The Floating (Pathogenicity) Island: A Genomic Dessert.
作者信息
Novick Richard P, Ram Geeta
机构信息
Department of Medicine, Skirball Institute, New York University Medical School, New York, NY 10016, USA; Department of Microbiology, Skirball Institute, New York University Medical School, New York, NY 10016, USA.
Department of Medicine, Skirball Institute, New York University Medical School, New York, NY 10016, USA; Department of Microbiology, Skirball Institute, New York University Medical School, New York, NY 10016, USA.
出版信息
Trends Genet. 2016 Feb;32(2):114-126. doi: 10.1016/j.tig.2015.11.005. Epub 2015 Dec 29.
Among the prokaryotic genomic islands (GIs) involved in horizontal gene transfer (HGT) are the classical pathogenicity islands, including the integrative and conjugative elements (ICEs), the gene-transfer agents (GTAs), and the staphylococcal pathogenicity islands (SaPIs), the primary focus of this review. While the ICEs and GTAs mediate HGT autonomously, the SaPIs are dependent on specific phages. The ICEs transfer primarily their own DNA, the GTAs exclusively transfer unlinked host DNA, and the SaPIs combine the capabilities of both. Thus the SaPIs derive their importance from the genes they carry (their genetic cargo) and the genes they move. They act not only as versatile high-frequency mobilizers but also as mediators of phage interference and consequently are major benefactors of their host bacteria.
参与水平基因转移（HGT）的原核生物基因组岛（GIs）包括经典的致病岛，如整合性接合元件（ICEs）、基因转移因子（GTAs）和葡萄球菌致病岛（SaPIs），后者是本综述的主要关注点。虽然ICEs和GTAs可自主介导HGT，但SaPIs依赖于特定噬菌体。ICEs主要转移自身DNA，GTAs只转移不相连的宿主DNA，而SaPIs兼具两者的能力。因此，SaPIs的重要性源于它们携带的基因（其遗传载荷）以及它们转移的基因。它们不仅是多功能的高频移动因子，还是噬菌体干扰的介质，因此是其宿主细菌的主要受益者。
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