致病岛及其在葡萄球菌生物学中的作用。
Pathogenicity Islands and Their Role in Staphylococcal Biology.
机构信息
NYU School of Medicine, Skirball Institute of Biomolecular Medicine and Departments of Medicine and Microbiology, New York, NY 10016.
出版信息
Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.GPP3-0062-2019.
Abstract
Pathogenicity islands are members of a vast collection of genomic islands that encode important virulence, antibiotic resistance and other accessory functions and have a critical role in bacterial gene transfer. is host to a large family of such islands, known as SaPIs, which encode super antigen and other virulence determinants, are mobilized by helper phages and transferred at extremely high frequencies. They benefit their host cells by interfering with phage predation and enhancing horizontal gene transfer. This chapter describes their life cycle, the bases of their phage interference mechanisms, their transfer system and their conversion to antibacterial agents for treatment ofstaphylococcal infections.
摘要
致病岛是基因组岛的一个庞大集合的成员，它们编码重要的毒力、抗生素耐药性和其他辅助功能，在细菌基因转移中起着关键作用。 是一大类这样的岛屿的宿主，这些岛屿被称为 SaPIs，它们编码超抗原和其他毒力决定因素，由辅助噬菌体动员，并以极高的频率转移。 它们通过干扰噬菌体捕食和增强水平基因转移来使宿主细胞受益。 本章描述了它们的生命周期、噬菌体干扰机制的基础、它们的转移系统以及它们转化为治疗葡萄球菌感染的抗菌剂。
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