Akende Oluwatosin, Akanbi Olusola Anuoluwapo, Oluremi Adeolu Sunday, Okonko Iheanyi Omezuruike, Opaleye Oluyinka Oladele
a Department of Medical Microbiology and Parasitology , College of Health Sciences, Ladoke Akintola University of Technology , Osogbo , Nigeria.
b Medical Microbiology Unit, Department of Microbiology , University of Port Harcourt , Port Harcourt , Rivers State , Nigeria.
J Immunoassay Immunochem. 2016;37(3):289-95. doi: 10.1080/15321819.2015.1132230.
Cytomegalovirus (CMV) is one of the predominant viral infections that lead to congenital diseases and teratogenic risks during the perinatal stage. There is paucity of seroepidemiological data on anti-CMV IgG antibody in pregnant women in Osogbo, Osun State, Nigeria. This study was aimed at determining the seroprevalence of Cytomegalovirus IgG antibody among pregnant women visiting antenatal clinic, LAUTECH Teaching Hospital, Osogbo, Nigeria. One hundred and seventy-four sera from the pregnant women were screened by Enzyme linked Immunosorbent Assay (ELISA) for cytomegalovirus (CMV) IgG antibody. Data analysis was done using SPSS software. In this study, 105 of the 174 pregnant women were seropositive for CMV IgG antibodies giving an antibody prevalence of 60%. There was no association found between CMV IgG seropositivity and the subjects' demographic characteristics, however, the 60.0% prevalence of CMV-IgG antibody observed amongst pregnant women in this study demands for vaccines and regular testing for the presence of CMV and its related risk factors in antenatal clinic.
巨细胞病毒（CMV）是导致围产期先天性疾病和致畸风险的主要病毒感染之一。在尼日利亚奥孙州奥索博，关于孕妇抗CMV IgG抗体的血清流行病学数据匮乏。本研究旨在确定在尼日利亚奥索博LAUTECH教学医院产前门诊就诊的孕妇中巨细胞病毒IgG抗体的血清流行率。采用酶联免疫吸附测定（ELISA）法对174名孕妇的血清进行巨细胞病毒（CMV）IgG抗体筛查。使用SPSS软件进行数据分析。在本研究中，174名孕妇中有105名CMV IgG抗体血清学阳性，抗体流行率为60%。未发现CMV IgG血清学阳性与受试者人口统计学特征之间存在关联，然而，本研究中孕妇中观察到的60.0%的CMV-IgG抗体流行率要求在产前门诊进行疫苗接种以及定期检测CMV及其相关风险因素。
