埃及孕妇巨细胞病毒原发性感染的确诊：采用巨细胞病毒 IgG 亲和性检测。
Primary cytomegalovirus infection in pregnant Egyptian women confirmed by cytomegalovirus IgG avidity testing.
机构信息
Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
出版信息
Med Princ Pract. 2014;23(1):29-33. doi: 10.1159/000354758. Epub 2013 Sep 13.
OBJECTIVE
To determine the frequency of primary cytomegalovirus (CMV) infection in pregnant Egyptian women using CMV IgG avidity testing.
SUBJECTS AND METHODS
A cross-sectional study was conducted at Suez Canal University Hospital, Ismailia, Egypt. A total of 546 pregnant women, presenting for routine antenatal screening, were tested for CMV IgG and IgM using a commercially available enzyme-linked immunosorbent assay (ELISA). Sera from CMV IgM-positive women were tested by CMV IgG avidity assay.
RESULTS
All the 546 pregnant women were seropositive for anti-CMV IgG. Of the 546 women, 40 (7.3%) were positive or equivocal for IgM antibodies. All sera from the 40 women (IgG+/IgM+) showed a high or intermediate CMV IgG avidity index. Of the 40 women, 23 (57.5%) were in the second or third trimesters of pregnancy and had their first-trimester blood retrieved, and the tested CMV IgG avidity assay showed a high avidity index.
CONCLUSION
Women who were IgM positive had no primary CMV infection in the index pregnancy as evidenced by the high CMV IgG avidity testing.
目的
通过巨细胞病毒（CMV）IgG 亲和力检测，确定埃及孕妇原发性 CMV 感染的频率。
对象与方法
本研究为横断面研究，在埃及伊斯梅利亚苏伊士运河大学医院进行。共检测了 546 名接受常规产前筛查的孕妇的 CMV IgG 和 IgM，使用的是市售酶联免疫吸附试验（ELISA）。对 CMV IgM 阳性的妇女的血清进行 CMV IgG 亲和力检测。
结果
所有 546 名孕妇的抗 CMV IgG 均呈阳性。在 546 名妇女中，40 名（7.3%）的 IgM 抗体阳性或可疑。40 名妇女（IgG+/IgM+）的所有血清均显示出高或中等 CMV IgG 亲和力指数。在这 40 名妇女中，23 名（57.5%）处于妊娠的第二或第三个三个月，并取回了她们的孕早期血样，检测的 CMV IgG 亲和力试验显示高亲和力指数。
结论
IgM 阳性的妇女在本次妊娠中没有原发性 CMV 感染，这一点可通过高 CMV IgG 亲和力检测来证明。
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