Zakrzewska Joanna, Buchanan John A G
Division of Diagnostic, Surgical and Medical Sciences, Eastman Dental Hospital, UCLH NHS Foundation, London, UK.
BMJ Clin Evid. 2016 Jan 7;2016:1301.
Burning mouth syndrome mainly affects women, particularly after the menopause, when its prevalence may be 18% to 33%.
We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of selected treatments for burning mouth syndrome? We searched: Medline, Embase, The Cochrane Library, and other important databases up to January 2015 (Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview).
At this update, searching of electronic databases retrieved 70 studies. After deduplication and removal of conference abstracts, 45 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 25 studies and the further review of 20 full publications. Of the 20 full articles evaluated, one systematic review and nine RCTs were added at this update. We performed a GRADE evaluation for five PICO combinations.
In this systematic overview, we categorised the efficacy for six interventions based on information about the effectiveness and safety of alphalipoic acid, benzodiazepines, benzydamine hydrochloride, cognitive behavioural therapy (CBT), selective serotonin re-uptake inhibitors (SSRIs), and tricyclic antidepressants.
灼口综合征主要影响女性，尤其是在绝经后，此时其患病率可能为18%至33%。
我们进行了一项系统综述，旨在回答以下临床问题：灼口综合征的选定治疗方法有哪些效果？我们检索了：截至2015年1月的医学期刊数据库（Medline）、荷兰医学文摘数据库（Embase）、考克兰图书馆及其他重要数据库（临床证据综述会定期更新；请查看我们的网站以获取此综述的最新版本）。
在此次更新时，检索电子数据库获得了70项研究。在去除重复项和会议摘要后，筛选了45条记录以纳入综述。对标题和摘要的评估导致排除了25项研究，并对20篇全文进行了进一步审查。在此次更新中，对评估的20篇全文，增加了一项系统评价和九项随机对照试验。我们对五个PICO组合进行了GRADE评估。
在本系统综述中，我们根据有关α硫辛酸、苯二氮卓类药物、盐酸苄达明、认知行为疗法（CBT）、选择性5-羟色胺再摄取抑制剂（SSRIs）和三环类抗抑郁药的有效性和安全性信息，对六种干预措施的疗效进行了分类。
