McGahan M C, Grimes A M, Fleisher L N
Department of Anatomy, School of Veterinary Medicine, North Carolina State University, Raleigh.
Ophthalmic Res. 1989;21(3):221-5. doi: 10.1159/000266811.
Ferroxidase activity was increased in the aqueous humor from inflamed eyes compared to their uninflamed contralateral controls 24 h after intravitreal injection of 10 ng of endotoxin. Changes in ferroxidase activity and copper concentration paralleled each other indicating that the plasma copper transport protein ceruloplasmin (plasma ferroxidase) entered the inflamed aqueous humor from plasma through disrupted blood ocular barriers. The presence of ferroxidase activity would facilitate the removal of potentially damaging, free radical generating Fe+2. Therefore, plasma proteins may perform important protective functions in the inflamed intraocular fluids.
玻璃体内注射10 ng内毒素24小时后，与未发炎的对侧对照眼相比，发炎眼房水中的铁氧化酶活性增加。铁氧化酶活性和铜浓度的变化相互平行，表明血浆铜转运蛋白铜蓝蛋白（血浆铁氧化酶）通过受损的血眼屏障从血浆进入发炎的房水。铁氧化酶活性的存在将有助于清除潜在有害的、产生自由基的Fe+2。因此，血浆蛋白可能在发炎的眼内液中发挥重要的保护作用。
