McGahan M C
Department of Anatomy, Physiology and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
Agents Actions. 1990 Aug;31(1-2):59-64. doi: 10.1007/BF02003222.
Copper (Cu) complexes of a number of compounds have increased anti-inflammatory efficacy over the native compound. In the present study, Cu and acetylsalicylic acid (ASA) were administered to rabbits over a one week period. At the end of this time, ocular inflammation was induced by intravitreal injection of endotoxin. ASA caused a slight reduction in the inflammatory response at 24 hours, but this response was not further decreased when Cu was added to the treatment regimen. However, there was a gradual and significant increase in antioxidant activity in the plasma of animals in the combined treatment group which could not be accounted for by a Cu-ASA complex, an increase in the concentration of known plasma protein antioxidants (ceruloplasmin and transferrin) or an increase in superoxide dismutase activity. The compound(s) responsible for this increased activity has a molecular weight greater than 10,000 Da. A large increase in plasma antioxidant activity may have a protective effect in other models of inflammation and provide a mechanism for the proven increase in anti-inflammatory efficacy of Cu-chelates of many compounds.
多种化合物的铜（Cu）配合物比天然化合物具有更高的抗炎功效。在本研究中，在一周的时间内给兔子施用铜和乙酰水杨酸（ASA）。在此时间段结束时，通过玻璃体内注射内毒素诱导眼部炎症。ASA在24小时时使炎症反应略有降低，但当在治疗方案中加入铜时，这种反应并未进一步降低。然而，联合治疗组动物血浆中的抗氧化活性有逐渐且显著的增加，这不能用铜 - ASA配合物、已知血浆蛋白抗氧化剂（铜蓝蛋白和转铁蛋白）浓度的增加或超氧化物歧化酶活性的增加来解释。导致这种活性增加的化合物分子量大于10,000 Da。血浆抗氧化活性的大幅增加可能在其他炎症模型中具有保护作用，并为许多化合物的铜螯合物抗炎功效的证实增加提供一种机制。
