Shadjou Nasrin, Hasanzadeh Mohammad
Department of Nanochemistry, Nano Technology Research Center and Faculty of Chemistry, Urmia University, Urmia, Iran.
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 51664, Iran.
J Biomed Mater Res A. 2016 May;104(5):1250-75. doi: 10.1002/jbm.a.35645. Epub 2016 Jan 29.
Tissue engineering and regenerative medicine represent areas of increasing interest because of the major progress in cell and organ transplantation, as well as advances in materials science and engineering. Tissue-engineered bone constructs have the potential to alleviate the demand arising from the shortage of suitable autograft and allograft materials for augmenting bone healing. Graphene and its derivatives have attracted much interest for applications in bone tissue engineering. For this purpose, this review focuses on more recent advances in tissue engineering based on graphene-biomaterials from 2013 to May 2015. The purpose of this article was to give a general description of studies of nanostructured graphene derivatives for bone tissue engineering. In this review, we highlight how graphene family nanomaterials are being exploited for bone tissue engineering. Firstly, the main requirements for bone tissue engineering were discussed. Then, the mechanism by which graphene based materials promote new bone formation was explained, following which the current research status of main types of nanostructured scaffolds for bone tissue engineering was reviewed and discussed. In addition, graphene-based bioactive glass, as a potential drug/growth factor carrier, was reviewed which includes the composition-structure-drug delivery relationship and the functional effect on the tissue-stimulation properties. Also, the effect of structural and textural properties of graphene based materials on development of new biomaterials for production of bone implants and bone cements were discussed. Finally, the present review intends to provide the reader an overview of the current state of the graphene based biomaterials in bone tissue engineering, its limitations and hopes as well as the future research trends for this exciting field of science.
由于细胞和器官移植取得的重大进展以及材料科学与工程的进步，组织工程和再生医学成为越来越受关注的领域。组织工程骨构建体有潜力缓解因用于促进骨愈合的合适自体移植和异体移植材料短缺而产生的需求。石墨烯及其衍生物在骨组织工程应用中引起了广泛关注。为此，本综述聚焦于2013年至2015年5月基于石墨烯 - 生物材料的组织工程的最新进展。本文旨在对用于骨组织工程的纳米结构石墨烯衍生物的研究进行总体描述。在本综述中，我们重点介绍了石墨烯家族纳米材料如何被用于骨组织工程。首先，讨论了骨组织工程的主要要求。然后，解释了基于石墨烯的材料促进新骨形成的机制，接着回顾并讨论了骨组织工程主要类型纳米结构支架的当前研究现状。此外，对基于石墨烯的生物活性玻璃作为潜在的药物/生长因子载体进行了综述，包括其组成 - 结构 - 药物递送关系以及对组织刺激特性的功能影响。还讨论了基于石墨烯的材料的结构和织构性质对用于生产骨植入物和骨水泥的新型生物材料开发的影响。最后，本综述旨在为读者提供基于石墨烯的生物材料在骨组织工程中的当前状态概述，其局限性与希望以及这一令人兴奋的科学领域的未来研究趋势。
