[Significance of seemingly intact urothelium in patients with bladder cancer].

During 9 years (from 1979 to 1988) the authors performed 412 multiple cold biopsies taken from 9 different points of the cancerous bladder in 263 patients. In 42 per cent of the patients the hystopathological examination of biopsy materials discovered dysplasia, carcinoma in situ or tumor of the grossly normal urothelium. The frequency of these proliferative lesions is closely connected with number, configuration, grading and depth of infiltration of overt bladder tumor. These lesions indicate the probable recurrence-rate as well as danger of the more progressive recurrence.