Flamm Andrea Gabriele, Żerko Szymon, Zawadzka-Kazimierczuk Anna, Koźmiński Wiktor, Konrat Robert, Coudevylle Nicolas
Department of Computational and Structural Biology, Max F. Perutz Laboratories, University of Vienna, Campus Vienna Biocenter 5, 1030, Vienna, Austria.
Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Żwirki i Wigury 101, 02-089, Warsaw, Poland.
Biomol NMR Assign. 2016 Apr;10(1):171-4. doi: 10.1007/s12104-015-9660-9. Epub 2016 Jan 9.
GAP-43 is a 25 kDa neuronal intrinsically disordered protein, highly abundant in the neuronal growth cone during development and regeneration. The exact molecular function(s) of GAP-43 remains unclear but it appears to be involved in growth cone guidance and actin cytoskeleton organization. Therefore, GAP-43 seems to play an important role in neurotransmitter vesicle fusion and recycling, long-term potentiation, spatial memory formation and learning. Here we report the nearly complete assignment of recombinant human GAP-43.
GAP-43是一种25 kDa的神经元内在无序蛋白，在发育和再生过程中的神经元生长锥中高度丰富。GAP-43的确切分子功能尚不清楚，但它似乎参与生长锥导向和肌动蛋白细胞骨架组织。因此，GAP-43似乎在神经递质囊泡融合与循环、长时程增强、空间记忆形成和学习中发挥重要作用。在此，我们报告重组人GAP-43的近乎完全归属。
