软珊瑚柔指软珊瑚中的新型二降单萜类化合物——莫利索内酯A和B。

Mollisolactones A and B, novel dinormonoterpenes from the soft coral Sinularia mollis.

作者信息

Cheng Shi-Yie, Wang Shang-Kwei, Ou Yih-Hsin, Duh Chang-Yih

机构信息

Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan.

Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

出版信息

Bioorg Med Chem Lett. 2016 Feb 1;26(3):879-881. doi: 10.1016/j.bmcl.2015.12.076. Epub 2015 Dec 22.

DOI:10.1016/j.bmcl.2015.12.076

PMID:26748693

Abstract

Two novel dinormonoterpenes, designated as mollisolactones A and B, were discovered from the soft coral Sinularia mollis on the basis of a chromatographic and NMR spectroscopy-based fractionation. Their structures were solved through analysis of comprehensive 1D and 2D NMR spectroscopic data and HRESIMS experiments. The biological activities of the obtained metabolites were evaluated for cytotoxicity against A-459 (human lung carcinoma), HT-29 (human colon adenocarcinoma), and P-388 (mouse lymphocytic leukemia) cancer cell lines as well as antiviral activity against HCMV (human cytomegalovirus).

摘要

基于色谱法和核磁共振光谱法分馏，从软珊瑚中华软珊瑚中发现了两种新型二降单萜，命名为软珊瑚内酯A和B。通过综合分析一维和二维核磁共振光谱数据以及高分辨电喷雾电离质谱实验确定了它们的结构。对所获得代谢产物的生物活性进行了评估，检测其对A-459（人肺癌）、HT-29（人结肠腺癌）和P-388（小鼠淋巴细胞白血病）癌细胞系的细胞毒性以及对人巨细胞病毒（HCMV）的抗病毒活性。