Asia-Pacific Ocean Research Center, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Mar Drugs. 2012 Jul;10(7):1528-1535. doi: 10.3390/md10071528. Epub 2012 Jul 17.
Paralemnolide A (1), possessing an unprecedented bisnorsesquiterpene skeleton, was isolated from the soft coral Paralemnalia thyrsoides. The structure of paralemnolide A was elucidated by extensive analysis of spectroscopic data. The anti-HCMV (human cytomegalovirus) activity of 1 and its cytotoxicity against selected cell lines were evaluated.
从软珊瑚 Paralemnalia thyrsoides 中分离得到了具有前所未有的双倍半萜骨架的 paralemnolide A(1)。通过对光谱数据的广泛分析阐明了 paralemnolide A 的结构。评估了 1 对 HCMV(人巨细胞病毒)的抗病毒活性及其对选定细胞系的细胞毒性。