Gupta Neha, Imam Reja Shahi, Bhalla Vandana, Gupta Muskan, Kaur Gurcharan, Kumar Manoj
Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, India.
Department of Biotechnology, Guru Nanak Dev University, Amritsar, 143005, India.
Chem Asian J. 2016 Apr 5;11(7):1020-7. doi: 10.1002/asia.201501333. Epub 2016 Mar 1.
A naphthalimide-based fluorescent probe, LyNP-NO, was designed and synthesized for the selective detection of exogenously and endogenously generated nitric oxide (NO) in C6 glial cells. In addition, LyNP-NO was also explored for monitoring endogenous NO levels in rat hippocampus at various tissue depths by stimulating the brain with N-methyl-d-aspartate (NMDA).
设计并合成了一种基于萘酰亚胺的荧光探针LyNP-NO，用于选择性检测C6神经胶质细胞中外源性和内源性产生的一氧化氮（NO）。此外，还通过用N-甲基-D-天冬氨酸（NMDA）刺激大脑，研究了LyNP-NO在大鼠海马体不同组织深度监测内源性NO水平的能力。
