一种可靶向溶酶体的荧光探针，用于活细胞中过氧化氢的内源性成像。
A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells.
作者信息
Reja Shahi Imam, Gupta Muskan, Gupta Neha, Bhalla Vandana, Ohri Puja, Kaur Gurcharan, Kumar Manoj
机构信息
Department of Chemistry, UGC Sponsored Centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar, Punjab, India.
Department of Biotechnology, Guru Nanak Dev University, Amritsar, Punjab, India.
出版信息
Chem Commun (Camb). 2017 Mar 28;53(26):3701-3704. doi: 10.1039/c6cc09127j.
A lysosome targetable naphthalimide based fluorescent probe (LyNC) has been designed and synthesized which detects hydrogen peroxide (HO) with high selectivity and sensitivity in brain tissues and in living nematodes among various ROS/RNS tested. Further, the probe LyNC was successfully employed in exogenous and endogenous imaging of HO in living cell lines.
一种可靶向溶酶体的基于萘二甲酰亚胺的荧光探针（LyNC）已被设计并合成出来，该探针在各种测试的活性氧/氮化物中，能在脑组织和活体线虫中高选择性且灵敏地检测过氧化氢（HO）。此外，探针LyNC已成功用于活细胞系中HO的外源性和内源性成像。
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