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本文引用的文献

1
Suppressive Effects of Insulin on Tumor Necrosis Factor-Dependent Early Osteoarthritic Changes Associated With Obesity and Type 2 Diabetes Mellitus.胰岛素对肥胖和 2 型糖尿病相关肿瘤坏死因子依赖性早期骨关节炎变化的抑制作用。
Arthritis Rheumatol. 2016 Jun;68(6):1392-402. doi: 10.1002/art.39561.
2
Association between diabetes mellitus and osteoarthritis: systematic literature review and meta-analysis.糖尿病与骨关节炎的相关性：系统文献回顾和荟萃分析。
RMD Open. 2015 Jun 2;1(1):e000077. doi: 10.1136/rmdopen-2015-000077. eCollection 2015.
3
Metabolic stress-induced joint inflammation and osteoarthritis.代谢应激诱导的关节炎症和骨关节炎。
Osteoarthritis Cartilage. 2015 Nov;23(11):1955-65. doi: 10.1016/j.joca.2015.05.016. Epub 2015 May 30.
4
Diabetes reduces mesenchymal stem cells in fracture healing through a TNFα-mediated mechanism.糖尿病通过肿瘤坏死因子α介导的机制减少骨折愈合过程中的间充质干细胞。
Diabetologia. 2015 Mar;58(3):633-642. doi: 10.1007/s00125-014-3470-y. Epub 2015 Jan 7.
5
Modulation of TNF-induced macrophage polarization by synovial fibroblasts.滑膜成纤维细胞对肿瘤坏死因子诱导的巨噬细胞极化的调节作用。
J Immunol. 2014 Sep 1;193(5):2373-83. doi: 10.4049/jimmunol.1400486. Epub 2014 Jul 23.
6
Inducible chondrocyte-specific overexpression of BMP2 in young mice results in severe aggravation of osteophyte formation in experimental OA without altering cartilage damage.在幼年小鼠中诱导性软骨细胞特异性过表达 BMP2 会导致实验性 OA 中骨赘形成的严重加重，而不会改变软骨损伤。
Ann Rheum Dis. 2015 Jun;74(6):1257-64. doi: 10.1136/annrheumdis-2013-204528. Epub 2014 Jan 21.
7
Local insulin therapy affects fracture healing in a rat model.局部胰岛素治疗影响大鼠模型骨折愈合。
J Orthop Res. 2013 May;31(5):776-82. doi: 10.1002/jor.22287. Epub 2012 Dec 13.
8
Diabetes is an independent predictor for severe osteoarthritis: results from a longitudinal cohort study.糖尿病是严重骨关节炎的独立预测因素：一项纵向队列研究的结果。
Diabetes Care. 2013 Feb;36(2):403-9. doi: 10.2337/dc12-0924. Epub 2012 Sep 21.
9
Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study.代谢危险因素（如超重、高血压、血脂异常和糖耐量受损）的积累会增加膝骨关节炎的发生和进展风险：ROAD 研究的 3 年随访结果。
Osteoarthritis Cartilage. 2012 Nov;20(11):1217-26. doi: 10.1016/j.joca.2012.06.006. Epub 2012 Jul 14.
10
Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance.抗肿瘤坏死因子治疗可改善高胰岛素抵抗的活动期类风湿关节炎患者的胰岛素抵抗、β细胞功能和胰岛素信号转导。
Arthritis Res Ther. 2012 Jun 12;14(3):R141. doi: 10.1186/ar3874.

Editorial: Insulin Resistance: Releasing the Brakes on Synovial Inflammation and Osteoarthritis?

作者信息

Griffin Timothy M, Huffman Kim M

机构信息

Oklahoma Medical Research Foundation and the University of Oklahoma Health Sciences Center, Oklahoma City.

Duke University Medical Center and Durham VA Medical Center, Durham, North Carolina.

出版信息

Arthritis Rheumatol. 2016 Jun;68(6):1330-3. doi: 10.1002/art.39586.

DOI:10.1002/art.39586
PMID:26749517
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5371020/
Abstract
摘要