Yukioka K, Wakitani S, Yukioka M, Furumitsu Y, Shichikawa K, Ochi T, Goto H, Matsui-Yuasa I, Otani S, Nishizawa Y
Yukioka Hospital, Osaka, Japan.
J Rheumatol. 1992 May;19(5):689-92.
We determined the polyamine contents of the synovial tissues from 11 patients with rheumatoid arthritis (RA), and the free putrescine levels in the synovial fluids (SF) from 10 patients with RA, 7 with osteoarthritis (OA), 5 with posttraumatic arthritis, and 3 with infectious arthritis. Putrescine levels in the synovial tissues correlated with serum C reactive protein concentration in patients with RA. Free putrescine levels in SF were significantly elevated in patients with infectious arthritis, compared with those found in RA, OA, and posttraumatic arthritis. Free putrescine levels in SF from patients with RA were significantly higher than in those with OA. Our findings suggest that polyamines may play an important role in RA.
我们测定了11例类风湿关节炎（RA）患者滑膜组织中的多胺含量，以及10例RA患者、7例骨关节炎（OA）患者、5例创伤后关节炎患者和3例感染性关节炎患者滑液（SF）中的游离腐胺水平。RA患者滑膜组织中的腐胺水平与血清C反应蛋白浓度相关。与RA、OA和创伤后关节炎患者相比，感染性关节炎患者SF中的游离腐胺水平显著升高。RA患者SF中的游离腐胺水平显著高于OA患者。我们的研究结果表明，多胺可能在RA中起重要作用。
