泰国成年腹泻住院患者中分离出的空肠弯曲菌和结肠弯曲菌的患病率及耐药性
Prevalence and Antimicrobial Resistance of Campylobacterjejuni and Campylobacter coli from Adult Hospitalized Patients with Diarrhea in Thailand.
作者信息
Pham Ngan Thi Kim, Ushijima Hiroshi, Trinh Quang Duy, Khamrin Pattara, Komine-Aizawa Shihoko, Okitsu Shoko, Maneekarn Niwat, Hayakawa Satoshi
出版信息
Clin Lab. 2015;61(11):1809-12. doi: 10.7754/clin.lab.2015.150415.
BACKGROUND
Infection with Campylobacter jejuni and C. coli are recognized as the major cause of bacterial gastroenteritis in humans.
METHODS
A total of 310 fecal samples collected from Thai adult patients with diarrhea in 2008 were screened for the presence of Campylobacter by PCR. Resistance to fluoroquinolone and macrolides of the detected Campylobacter strains were analyzed by studying the mutations in the gyrA and 23S rRNA genes, respectively.
RESULTS
Campylobacter species were detected in 4/310 (1.3%) of diarrheal patients, and C. jejuni was found in 3 of the 4 cases (75%). Fluoroquinolone resistance was noted in 2 cases (50%); however, no resistance to macrolides was observed.
CONCLUSIONS
Campylobacter was detected in a low prevalence in adult Thai patients hospitalized with diarrhea, and the resistance to fluoroquinolones is still a matter of concern in case antibiotic therapy is required.
背景
空肠弯曲菌和结肠弯曲菌感染被认为是人类细菌性肠胃炎的主要病因。
方法
2008年从泰国成年腹泻患者中收集了310份粪便样本，通过聚合酶链反应（PCR）筛查弯曲菌的存在情况。分别通过研究gyrA基因和23S核糖体RNA（rRNA）基因的突变，分析检测到的弯曲菌菌株对氟喹诺酮类和大环内酯类药物的耐药性。
结果
在4/310（1.3%）的腹泻患者中检测到弯曲菌属，4例中有3例（75%）检测到空肠弯曲菌。2例（50%）出现氟喹诺酮耐药；然而，未观察到对大环内酯类药物的耐药情况。
结论
在因腹泻住院的泰国成年患者中，弯曲菌的检出率较低，若需要进行抗生素治疗，对氟喹诺酮类药物的耐药性仍是一个值得关注的问题。
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