De Palo C, Macor C, Sicolo N, Vettor R, Scandellari C, Federspil G
Istituto di Semeiotica Medica, Patologia Medica III, Università degli Studi di Padova, Italy.
Acta Diabetol Lat. 1989 Apr-Jun;26(2):155-62. doi: 10.1007/BF02581367.
The possibility that dietary-induced thermogenesis may be decreased in obesity has been proposed in recent years. However, the results of human studies so far obtained are conflicting. The present research was undertaken in order to clarify this question. We studied postprandial thermogenesis induced by ingestion of a mixed meal and of a carbohydrate mixture in 15 normal and 12 obese subjects. Blood glucose and plasma insulin levels were measured at the same time. The data obtained have shown that the mean resting metabolic rate (RMR) expressed as a function of body weight3/4, is almost the same in obese as in normal-weight subjects (0.115 +/- 0.018 vs 0.133 +/- 0.021 kj/min/kg3/4, respectively). Moreover, the increment of mixed-meal induced thermogenesis (MM-IT) was 48 +/- 22% in normal and -0.8 +/- 12% in obese subjects, respectively (p less than 0.01). Carbohydrate induced thermogenesis (CHO-IT) appeared slightly higher in normal-weight than in obese subjects (159 +/- 66 vs 98 +/- 46). After carbohydrate ingestion we observed a higher glycemic and insulinemic response in obesity. These results indicate that thermogenesis induced by ingestion of food is reduced in obese subjects; they are also compatible with the idea that insulin resistance could play a role in this phenomenon.
近年来有人提出，肥胖可能会使饮食诱导产热减少。然而，目前已获得的人体研究结果相互矛盾。开展本研究是为了阐明这一问题。我们对15名正常体重受试者和12名肥胖受试者摄入混合餐及碳水化合物混合物后餐后产热情况进行了研究。同时测量了血糖和血浆胰岛素水平。获得的数据表明，以体重的3/4为函数表示的平均静息代谢率（RMR），肥胖受试者与正常体重受试者几乎相同（分别为0.115±0.018与0.133±0.021千焦/分钟/千克3/4）。此外，混合餐诱导产热（MM-IT）的增量在正常体重受试者中为48±22%，在肥胖受试者中为-0.8±12%（p<0.01）。碳水化合物诱导产热（CHO-IT）在正常体重受试者中似乎略高于肥胖受试者（159±66与98±46）。摄入碳水化合物后，我们观察到肥胖者血糖和胰岛素反应更高。这些结果表明，肥胖受试者摄入食物后诱导的产热减少；它们也与胰岛素抵抗可能在这一现象中起作用的观点相符。
