Bertozzi Silva Juliano, Storms Zachary, Sauvageau Dominic
Department of Chemical and Materials Engineering, University of Alberta, 12th Floor, Donadeo Innovation Centre for Engineering, 9211-116 Street NW, Edmonton, AB T6G 1H9, Canada.
Department of Chemical and Materials Engineering, University of Alberta, 12th Floor, Donadeo Innovation Centre for Engineering, 9211-116 Street NW, Edmonton, AB T6G 1H9, Canada
FEMS Microbiol Lett. 2016 Feb;363(4). doi: 10.1093/femsle/fnw002. Epub 2016 Jan 10.
The adsorption of bacteriophages (phages) onto host cells is, in all but a few rare cases, a sine qua non condition for the onset of the infection process. Understanding the mechanisms involved and the factors affecting it is, thus, crucial for the investigation of host-phage interactions. This review provides a survey of the phage host receptors involved in recognition and adsorption and their interactions during attachment. Comprehension of the whole infection process, starting with the adsorption step, can enable and accelerate our understanding of phage ecology and the development of phage-based technologies. To assist in this effort, we have established an open-access resource--the Phage Receptor Database (PhReD)--to serve as a repository for information on known and newly identified phage receptors.
除少数罕见情况外，噬菌体吸附到宿主细胞上是感染过程开始的必要条件。因此，了解其中涉及的机制以及影响该过程的因素对于研究宿主 - 噬菌体相互作用至关重要。本综述概述了参与识别和吸附的噬菌体宿主受体及其在附着过程中的相互作用。从吸附步骤开始理解整个感染过程，能够促进并加速我们对噬菌体生态学以及基于噬菌体技术发展的理解。为辅助这项工作，我们建立了一个开放获取资源——噬菌体受体数据库（PhReD），作为已知和新鉴定的噬菌体受体信息的储存库。
Zotero 插件