聚乙二醇化蛋白的固态 NMR 研究。
Solid-State NMR of PEGylated Proteins.
机构信息
Magnetic Resonance Center (CERM) and Department of Chemistry "Ugo Schiff", University of Florence, and Magnetic Resonance Consortium (CIRMMP), Via L. Sacconi 6, 50019, Sesto Fiorentino, FI, Italy.
Giotto Biotech S.r.l. Via Madonna del Piano 6, 50019, Sesto Fiorentino, FI, Italy.
出版信息
Angew Chem Int Ed Engl. 2016 Feb 12;55(7):2446-9. doi: 10.1002/anie.201510148. Epub 2016 Jan 12.
PEGylated proteins are widely used in biomedicine but, in spite of their importance, no atomic-level information is available since they are generally resistant to structural characterization approaches. PEGylated proteins are shown here to yield highly resolved solid-state NMR spectra, which allows assessment of the structural integrity of proteins when PEGylated for therapeutic or diagnostic use.
聚乙二醇化蛋白质在生物医学中被广泛应用，但尽管它们很重要，却没有原子水平的信息，因为它们通常对结构表征方法具有抗性。本文表明，聚乙二醇化蛋白质可以产生高分辨率的固态 NMR 谱，这使得在用于治疗或诊断用途时对蛋白质的结构完整性进行评估成为可能。
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