Kennedy L, Lyons T J
Br Med Bull. 1989 Jan;45(1):174-90. doi: 10.1093/oxfordjournals.bmb.a072310.
Experience with the use of glycosylated haemoglobin throughout the 1980s has confirmed its uniqueness and usefulness as an objective index of long-term glycaemia in diabetes mellitus, and has enabled the definition of realistic and achievable targets for outpatient management. Measurement of glycosylated serum proteins yields information over a much shorter time-scale which may be particularly useful in diabetic pregnancy. The formation of advanced glycosylation end-products may provide a link between hyperglycaemia and chronic diabetic complications. Therapeutic inhibition or the promotion of alternative metabolic pathways, to yield inert glycosylated products, represents an innovative approach to the problem of preventing these complications.
20世纪80年代使用糖化血红蛋白的经验证实了其作为糖尿病长期血糖客观指标的独特性和实用性，并使得能够为门诊管理确定现实且可实现的目标。糖化血清蛋白的测定能在更短的时间范围内提供信息，这在糖尿病妊娠中可能特别有用。晚期糖基化终产物的形成可能在高血糖与慢性糖尿病并发症之间提供一种联系。治疗性抑制或促进替代代谢途径以产生惰性糖基化产物，代表了一种预防这些并发症问题的创新方法。
