Bradley Jessica M, Organ Chelsea L, Lefer David J
Department of Pharmacology and Experimental Therapeutics and Cardiovascular Center of Excellence, LSU Health Sciences Center, New Orleans, LA.
Department of Pharmacology and Experimental Therapeutics and Cardiovascular Center of Excellence, LSU Health Sciences Center, New Orleans, LA
J Nutr. 2016 Feb;146(2):403S-409S. doi: 10.3945/jn.114.208066. Epub 2016 Jan 13.
For centuries, garlic has been shown to exert substantial medicinal effects and is considered to be one of the best disease-preventative foods. Diet is important in the maintenance of health and prevention of many diseases including cardiovascular disease (CVD). Preclinical and clinical evidence has shown that garlic reduces risks associated with CVD by lowering cholesterol, inhibiting platelet aggregation, and lowering blood pressure. In recent years, emerging evidence has shown that hydrogen sulfide (H2S) has cardioprotective and cytoprotective properties. The active metabolite in garlic, allicin, is readily degraded into organic diallyl polysulfides that are potent H2S donors in the presence of thiols. Preclinical studies have shown that enhancement of endogenous H2S has an impact on vascular reactivity. In CVD models, the administration of H2S prevents myocardial injury and dysfunction. It is hypothesized that these beneficial effects of garlic may be mediated by H2S-dependent mechanisms. This review evaluates the current knowledge concerning the cardioprotective effects of garlic-derived diallyl polysulfides.
几个世纪以来，大蒜已被证明具有显著的药用功效，被认为是最佳的疾病预防食物之一。饮食对于维持健康和预防包括心血管疾病（CVD）在内的多种疾病至关重要。临床前和临床证据表明，大蒜通过降低胆固醇、抑制血小板聚集和降低血压来降低与心血管疾病相关的风险。近年来，新出现的证据表明，硫化氢（H2S）具有心脏保护和细胞保护特性。大蒜中的活性代谢产物大蒜素在硫醇存在的情况下很容易降解为有机二烯丙基多硫化物，而有机二烯丙基多硫化物是强效的H2S供体。临床前研究表明，内源性H2S的增强对血管反应性有影响。在心血管疾病模型中，给予H2S可预防心肌损伤和功能障碍。据推测，大蒜的这些有益作用可能是由H2S依赖性机制介导的。本综述评估了目前关于大蒜衍生的二烯丙基多硫化物心脏保护作用的知识。
