Endes Simon, Schaffner Emmanuel, Caviezel Seraina, Dratva Julia, Autenrieth Christine S, Wanner Miriam, Martin Brian, Stolz Daiana, Pons Marco, Turk Alexander, Bettschart Robert, Schindler Christian, Künzli Nino, Probst-Hensch Nicole, Schmidt-Trucksäss Arno
Department of Sport, Exercise and Health, Division of Sports and Exercise Medicine, University of Basel, 4052 Basel, Switzerland.
Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland.
Age Ageing. 2016 Jan;45(1):110-5. doi: 10.1093/ageing/afv172.
longitudinal analyses of physical activity (PA) and arterial stiffness in populations of older adults are scarce. We examined associations between long-term change of PA and arterial stiffness in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA).
we assessed PA in SAPALDIA 2 (2001-03) and SAPALDIA 3 (2010-11) using a short questionnaire with a cut-off of at least 150 min of moderate-to-vigorous PA per week for sufficient activity. Arterial stiffness was measured oscillometrically by means of the brachial-ankle pulse wave velocity (baPWV) in SAPALDIA 3. We used multivariable mixed linear regression models adjusted for several potential confounders in 2,605 persons aged 50-81.
adjusted means of baPWV were significantly lower in persons with sufficient moderate-to-vigorous PA (i) in SAPALDIA 2 but not in SAPALDIA 3 (P = 0.048) and (ii) in both surveys (P = 0.001) compared with persons with insufficient activity in both surveys. There was a significant interaction between sex and the level of change in PA concerning baPWV (P = 0.03). The triples of parameter estimates describing the association between level of PA change and baPWV were not significantly different between the two sex-specific models (P = 0.07).
keeping up or adopting a physically active lifestyle was associated with lower arterial stiffness in older adults after a follow-up of almost a decade. Increasing the proportion of older adults adhering to PA recommendations incorporating also vigorous PA may have a considerable impact on vascular health at older age and may contribute to healthy ageing in general.
对老年人身体活动（PA）和动脉僵硬度进行纵向分析的研究较少。我们在瑞士成人空气污染与心肺疾病队列研究（SAPALDIA）中，研究了PA的长期变化与动脉僵硬度之间的关联。
我们在SAPALDIA 2（2001 - 2003年）和SAPALDIA 3（2010 - 2011年）中使用简短问卷评估PA，将每周至少150分钟的中度至剧烈PA作为充足活动的标准。在SAPALDIA 3中，通过臂踝脉搏波速度（baPWV）采用示波法测量动脉僵硬度。我们在2605名年龄在50 - 81岁的人群中使用多变量混合线性回归模型，并对多个潜在混杂因素进行了调整。
与在两次调查中活动不足的人相比，（i）在SAPALDIA 2中但不在SAPALDIA 3中（P = 0.048）以及（ii）在两次调查中（P = 0.001），有充足中度至剧烈PA的人的baPWV调整均值显著更低。在性别与PA变化水平关于baPWV之间存在显著交互作用（P = 0.03）。描述PA变化水平与baPWV之间关联的参数估计三元组在两个性别特异性模型之间无显著差异（P = 0.07）。
在近十年的随访后，保持或采用积极的生活方式与老年人较低的动脉僵硬度相关。增加坚持包含剧烈PA的PA建议的老年人比例，可能对老年时的血管健康产生相当大的影响，并可能总体上有助于健康老龄化。
